Clinical and Immunological Factors in Emphysema Progression. Five-Year Prospective Longitudinal Exacerbation Study of Chronic Obstructive Pulmonary Disease (LES-COPD).

@article{Bhavani2015ClinicalAI,
  title={Clinical and Immunological Factors in Emphysema Progression. Five-Year Prospective Longitudinal Exacerbation Study of Chronic Obstructive Pulmonary Disease (LES-COPD).},
  author={Sivasubramanium Bhavani and C P Tsai and Sarah Perusich and Sean Hesselbacher and Harvey O Coxson and Lavannya M. Pandit and David B Corry and Farrah Kheradmand},
  journal={American journal of respiratory and critical care medicine},
  year={2015},
  volume={192 10},
  pages={1171-8}
}
RATIONALE Cross-sectional studies of T-cell responses to self-antigens correlate with baseline emphysema severity. OBJECTIVES We investigated whether clinical and/or immunological factors could predict disease progression, such as emphysema, FEV1, and 6-minute-walk distance (6MWD), in former and active smokers in a 5-year prospective study. METHODS We recruited 224 ever smokers over 40 years of age and with greater than a 15 pack-year smoking history. MEASUREMENTS AND MAIN RESULTS… CONTINUE READING
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