Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia.

  title={Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia.},
  author={Chengcheng Liu and Wenjian Yang and Meenakshi Devidas and Cheng Cheng and Deqing Pei and Colton A Smith and William L Carroll and Elizabeth A. Raetz and W. Paul Bowman and Eric C. Larsen and Kelly W. Maloney and Paul Langlie Martin and Leonard A. Mattano and Naomi Joan Winick and Elaine R. Mardis and Robert S. Fulton and Deepa Bhojwani and Scott C. Howard and Sima Jeha and Ching-Hon Pui and Stephen P Hunger and William E. Evans and Mignon L Loh and Mary V. Relling},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={34 18},
PURPOSE Acute pancreatitis is one of the common causes of asparaginase intolerance. The mechanism is unknown, and genetic predisposition to asparaginase-induced pancreatitis has not been previously identified. METHODS To determine clinical risk factors for asparaginase-induced pancreatitis, we studied a cohort of 5,185 children and young adults with acute lymphoblastic leukemia, including 117 (2.3%) who were diagnosed with at least one episode of acute pancreatitis during therapy. A genome… CONTINUE READING
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