Clinical and Biological Implications of MYC Activation: A common difference between MGUS and newly diagnosed multiple myeloma

@inproceedings{Chng2011ClinicalAB,
  title={Clinical and Biological Implications of MYC Activation: A common difference between MGUS and newly diagnosed multiple myeloma},
  author={W J Chng and G Z Huang and TH Chung and S. E. S. Ng and Natalia C Gonzalez-Paz and T Troska-Price and George J. Mulligan and Marta Chesi and P Leif Bergsagel and Rafael Fonseca},
  booktitle={Leukemia},
  year={2011}
}
Events mediating transformation from the pre-malignant monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM) are unknown. We analyzed gene expression data sets generated on the Affymetrix U133 platform from 22 MGUS and 101 MM patients using gene-set enrichment analysis. Genes overexpressed in MM were enriched for cell cycle, proliferation and MYC activation gene sets. Upon dissecting the relationship between MYC and cell-cycle gene sets, we identified and validated… CONTINUE READING
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