Clinical and Biological Effects of Valproic Acid as a Histone Deacetylase Inhibitor on Tumor and Surrogate Tissues: Phase I/II Trial of Valproic acid and Epirubicin/FEC

@article{Munster2009ClinicalAB,
  title={Clinical and Biological Effects of Valproic Acid as a Histone Deacetylase Inhibitor on Tumor and Surrogate Tissues: Phase I/II Trial of Valproic acid and Epirubicin/FEC},
  author={Pamela N. Munster and Douglas C. Marchion and Elona Biçaku and Mira Lacevic and Jongphil Kim and Barbara Ann Centeno and Adil I. Daud and Anthony M Neuger and Susan E. Minton and Daniel C. Sullivan},
  journal={Clinical Cancer Research},
  year={2009},
  volume={15},
  pages={2488 - 2496}
}
Purpose: The aim was to study the biological and molecular effects of the histone deacetylase (HDAC) inhibitor, valproic acid, in patients with solid tumor malignancies. Experimental Design: A phase I dose escalation of valproic acid given on days 1 to 3 followed by epirubicin (day 3) was followed by a dose expansion of valproic acid combined with 5-fluorouracil, epirubicin, and cyclophosphamide (FEC100). Pharmacodynamic and pharmacokinetic studies entailed valproic acid and epirubicin plasma… 
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Spontaneous Cancer
Download pose: Histone deacetylase inhibitors (HDACi) are targeted anticancer agents with a well-documenility to act synergistically with cytotoxic agents. We recently showed that the HDACi valproic…
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TLDR
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TLDR
It is demonstrated that VPA augments anticancer activity of cisplatin and etoposide, two components of the standard first-line chemotherapy of small cell lung cancer.
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TLDR
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Phase II clinical study of valproic acid plus cisplatin and cetuximab in recurrent and/or metastatic squamous cell carcinoma of Head and Neck-V-CHANCE trial
TLDR
This study could provide a less toxic and more effective first-line chemotherapy regimen in patients with recurrent/metastatic squamous cell carcinoma of the head and neck by demonstrating the feasibility and efficacy of cisplatin/cetuximab plus valproic acid.
A double-blind, placebo-controlled, randomized phase III trial of chemotherapy plus epigenetic therapy with hydralazine valproate for advanced cervical cancer. Preliminary results
TLDR
Although preliminary, this study represents the first randomized clinical trial to demonstrate a significant advantage in progression-free survival for epigenetic therapy over one of the current standard combination chemotherapy in cervical cancer.
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