Clinical and Biological Effects of Mifepristone Treatment for Psychotic Depression

  title={Clinical and Biological Effects of Mifepristone Treatment for Psychotic Depression},
  author={B. Flores and H. Kenna and J. Keller and H. Solvason and A. Schatzberg},
  • B. Flores, H. Kenna, +2 authors A. Schatzberg
  • Published 2006
  • Medicine, Psychology
  • Neuropsychopharmacology
  • Psychotic major depression (PMD) is found to be a relatively common psychiatric condition that affects up to nearly 20% of patients with major depression. Previous studies by our group have shown rapid reversal of psychotic symptoms in some PMD patients treated with mifepristone, in addition to restoring a more normal afternoon cortisol release. The rationale for treating patients with PMD with a glucocorticosteroid receptor antagonist is further discussed. In total, 30 patients with PMD were… CONTINUE READING

    Paper Mentions

    Approximately 450 patients will be randomized to receive mifepristone or placebo for 7 days followed by antidepressant. The purpose is to compare the efficacy of mifepristone followed… Expand
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