Clinical and Biological Effects of Mifepristone Treatment for Psychotic Depression

@article{Flores2006ClinicalAB,
  title={Clinical and Biological Effects of Mifepristone Treatment for Psychotic Depression},
  author={B. Flores and H. Kenna and J. Keller and H. Solvason and A. Schatzberg},
  journal={Neuropsychopharmacology},
  year={2006},
  volume={31},
  pages={628-636}
}
  • B. Flores, H. Kenna, +2 authors A. Schatzberg
  • Published 2006
  • Medicine, Psychology
  • Neuropsychopharmacology
  • Psychotic major depression (PMD) is found to be a relatively common psychiatric condition that affects up to nearly 20% of patients with major depression. Previous studies by our group have shown rapid reversal of psychotic symptoms in some PMD patients treated with mifepristone, in addition to restoring a more normal afternoon cortisol release. The rationale for treating patients with PMD with a glucocorticosteroid receptor antagonist is further discussed. In total, 30 patients with PMD were… CONTINUE READING

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    Approximately 450 patients will be randomized to receive mifepristone or placebo for 7 days followed by antidepressant. The purpose is to compare the efficacy of mifepristone followed… Expand
    ConditionsPsychosis, Psychotic Depression, Severe Major Depression With Psychotic Features
    InterventionDrug
    Metyrapone in treatment-resistant depression
    • 24
    • Open Access
    Reply: Clinical and Biological Effects of Mifepristone Treatment for Psychotic Treatment
    • 6
    • Open Access

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 43 REFERENCES
    Rapid Reversal of Psychotic Depression Using Mifepristone
    • 251
    An open label trial of C-1073 (mifepristone) for psychotic major depression*
    • 278
    • Open Access
    An 8-week open-label trial of a 6-day course of mifepristone for the treatment of psychotic depression.
    • 51
    Challenges in the treatment of depression with psychotic features
    • 92
    DST studies in psychotic depression: a meta-analysis.
    • 311
    A corticosteroid/dopamine hypothesis for psychotic depression and related states.
    • 220
    Neuropsychological deficits in psychotic versus nonpsychotic major depression and no mental illness.
    • 198
    • Open Access
    Psychotic depression and mortality.
    • 97