Clinical analysis of 17 patients in 12 Japanese families with autosomal-recessive type juvenile parkinsonism.

@article{Ishikawa1996ClinicalAO,
  title={Clinical analysis of 17 patients in 12 Japanese families with autosomal-recessive type juvenile parkinsonism.},
  author={Atsushi Ishikawa and Shoji Tsuji},
  journal={Neurology},
  year={1996},
  volume={47 1},
  pages={160-6}
}
We present the clinical features of 17 patients from 12 Japanese families with familial juvenile parkinsonism suggesting autosomal-recessive inheritance (AR-JP). Because the marriages of the parents in all but one family were consanguineous and all patients were only first generation, an autosomal-recessive trait was strongly suspected. Analysis of the clinical features showed female predominance, mean age at onset 27.8 years, and slow progression. The symptoms of the parkinsonian triad (tremor… CONTINUE READING