Clinical amyloid imaging in Alzheimer's disease.

  title={Clinical amyloid imaging in Alzheimer's disease.},
  author={Karl Herholz and Klaus P. Ebmeier},
  journal={The Lancet. Neurology},
  volume={10 7},
BACKGROUND The hypothesis that amyloid deposition is the leading cause of Alzheimer's disease (AD) is supported by findings in transgenic animal models and forms the basis of clinical trials of anti-amyloid agents. According to this theory, amyloid deposition causes severe damage to neurons many years before onset of dementia via a cascade of several downstream effects. This hypothesis has, however, not yet been directly tested in human beings because of the very limited possibility of… CONTINUE READING
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