Clinical administration of microneedles: skin puncture, pain and sensation.

@article{Haq2009ClinicalAO,
  title={Clinical administration of microneedles: skin puncture, pain and sensation.},
  author={Muhammad Israr ul Haq and Einar Smith and Dr. Neetha John and Manju Kalavala and Cedric Edwards and Alexander Vincent Anstey and Anthony Morrissey and James Caradoc Birchall},
  journal={Biomedical microdevices},
  year={2009},
  volume={11 1},
  pages={
          35-47
        }
}
Injections using hypodermic needles cause pain, discomfort, localised trauma and apprehension. Additionally, careful use and disposal of needles is required to avoid transmission of blood-borne pathogens. As an alternative, microneedles can facilitate drug delivery without significantly impacting on pain receptors or blood vessels that reside beneath the skin outer layers. In this study we aim to determine the pain and sensory response to the application of wet-etch silicon microneedles, when… CONTINUE READING
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