Clinical activity of pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in advanced ovarian cancer: potential predictive relationship with tumor HER2 activation status.

@article{Gordon2006ClinicalAO,
  title={Clinical activity of pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in advanced ovarian cancer: potential predictive relationship with tumor HER2 activation status.},
  author={Michael S Gordon and Daniela Elena Matei and Carol A. Aghajanian and Ursula A. Matulonis and Molly A. Brewer and Gini F. Fleming and John D Hainsworth and Agustin A. Garcia and Mark D. Pegram and Russell Schilder and David Cohn and Lynda Roman and Mika Kakefuda Derynck and Kimmie Ng and Benjamin P. Lyons and David E. Allison and David A. Eberhard and Thinh Q Pham and Randall C Dere and Beth Y. Karlan},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2006},
  volume={24 26},
  pages={4324-32}
}
PURPOSE Ovarian cancers (OCs) frequently have HER2 activation in the absence of HER2 overexpression. Pertuzumab, a humanized antibody that prevents HER2 dimerization and inhibits multiple HER-mediated pathways, was studied in a phase II, multicenter trial in advanced, refractory OC. PATIENTS AND METHODS Sixty-one patients (cohort 1) with relapsed OC received a loading dose of 840 mg pertuzumab intravenously followed by 420 mg every 3 weeks; 62 patients (cohort 2) received 1,050 mg every 3… CONTINUE READING
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