Clinical activity of folinic acid in patients with chronic fatigue syndrome.

@article{Lundell2006ClinicalAO,
  title={Clinical activity of folinic acid in patients with chronic fatigue syndrome.},
  author={Kathleen Lundell and S. Qazi and L. Eddy and F. Uckun},
  journal={Arzneimittel-Forschung},
  year={2006},
  volume={56 6},
  pages={
          399-404
        }
}
A high incidence of severe B-cell immunodeficiency and chronic reactivated Epstein-Barr virus (EBV) infection in patients with chronic fatigue syndrome (CFS) is reported herein. Of the 58 patients evaluated, 100% had evidence of prior EBV exposure and 72% had evidence for reactivated EBV infection. Notably, 94% of CFS patients had B-cell immunodeficiency with a marked depletion of their CD19+IgM+ mature B-lymphocyte population. A remarkable 81% of CFS patients experienced subjective improvement… Expand
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