Clinical Trials Update. 2013: Year in Review
@article{Peroutka2014ClinicalTU,
title={Clinical Trials Update. 2013: Year in Review},
author={Stephen J. Peroutka},
journal={Headache: The Journal of Head and Face Pain},
year={2014},
volume={54}
}This section of Headache annually reviews the status of recently completed and ongoing major clinical trials involving common headache disorders. The review will focus on multicenter trials of new therapies, as well as novel formulations of previously approved therapeutics. Table 1 summarizes the major therapeutic headache trials that are ongoing at the present time, according to data obtained from both the “ClinicalTrials.Gov” website and from corporate press releases and presentations.
6 Citations
New therapeutic approaches for the prevention and treatment of migraine
- BiologyThe Lancet Neurology
- 2015
Burning Mouth Syndrome Related to the Intake of Topiramate
- MedicineHeadache
- 2014
Two women aged 36 and 38, who were evaluated in the neurology department of Virgen Macarena Hospital, reported experiencing long-standing migraines without aura required preventive treatment of topiramate, and it was concluded that the active ingredient was the cause of Burning Mouth Syndrome.
BMS-927711 for the acute treatment of migraine
- MedicineCephalalgia : an international journal of headache
- 2014
The result of a large Phase 2b study testing BMS-927711 for the acute treatment of migraine showed that the drug was clearly effective at multiple doses, meaning that all CGRP receptor antagonists tested to date have demonstrated efficacy in Phase 2 and Phase 3 studies.
Monoclonal Antibodies for Migraine: Preventing Calcitonin Gene-Related Peptide Activity
- BiologyCNS Drugs
- 2014
An overview of the role of CGRP in the pathophysiology of migraine is provided, followed by a review of the clinical development of CgrP-RAs, and some basic concepts on antibodies are discussed along with the publicly disclosed information on the development of mAbs targeting the C GRP pathway.
Calcitonin Gene‐Related Peptide (CGRP) and Migraine Current Understanding and State of Development
- BiologyHeadache
- 2013
The role of C GRP in normal physiology and the consequences of CGRP inhibition for human homeostasis are discussed and the current state of development for CGRp‐receptor antagonists and CGRPs monoclonal antibodies is reviewed.