Clinical Treatment of Radiotherapy Tissue Damage by Lipoaspirate Transplant: A Healing Process Mediated by Adipose-Derived Adult Stem Cells

@article{Rigotti2007ClinicalTO,
  title={Clinical Treatment of Radiotherapy Tissue Damage by Lipoaspirate Transplant: A Healing Process Mediated by Adipose-Derived Adult Stem Cells},
  author={Gino Rigotti and Alessandra Marchi and Mirco Gali{\`e} and Guido Baroni and Donatella Benati and Mauro Krampera and Annalisa Pasini and Andrea Sbarbati},
  journal={Plastic and Reconstructive Surgery},
  year={2007},
  volume={119},
  pages={1409-1422}
}
Background: There is evidence that stem cells contribute to the restoration of tissue vascularization and organ function. The objective of this study was to assess the presence of adipose-derived adult stem cells left in their natural scaffold in the purified lipoaspirate and to assess the clinical effectiveness of lipoaspirate transplantation in the treatment of radiation side effects. Methods: This study was designed beginning with surgical procedures in 2002 and envisaging a continuous… 
Antiaging Treatment of the Facial Skin by Fat Graft and Adipose-Derived Stem Cells
TLDR
This study demonstrates that treatment with either fat and stromal vascular fraction or expanded mesenchymal stem cells modifies the pattern of the dermis, representing a skin rejuvenation effect.
Effects of Adipose-Derived Stem Cells and Platelet-Rich Plasma for Prevention of Alopecia and Other Skin Complications of Radiotherapy.
TLDR
Adipose-derived stem cells reduced RT-induced adverse effects by suppressing inflammation, dystrophy, degeneration, connective tissue synthesis, and apoptosis and increasing cellular proliferation, differentiation, and signaling.
Molecular Characterization of Lipoaspirates Used in Regenerative Head and Neck Surgery.
TLDR
The characteristics of lipoaspirates used in reconstructive head and neck surgical procedures with respect to wound healing were evaluated and the cells fulfilled the international accepted criteria for mesenchymal stem cells.
Adipose-Derived Stem Cells in Radiotherapy Injury: A New Frontier
TLDR
An overview of the current understanding of mechanisms of chronic radiation injury and its clinical manifestations; biological properties of fat grafts and their key constituent, adipose-derived stem cells (ADSCs); and the role of ADSCs in radiotherapy-induced soft-tissue injury are provided.
Adipose Tissue–Derived Regenerative Cell–Enhanced Lipofilling for Treatment of Cryptoglandular Fistulae-in-Ano
TLDR
Treatment of cryptoglandular fistulae-in-ano with ADRC-enhanced lipofilling appears feasible and safe, and may add to the range of procedures that can be used to treat this difficult problem.
Efficacy of adipose-derived stromal vascular fraction cells in the management of chronic ulcers: a randomized clinical trial.
TLDR
This study investigates the autologous stem cell yield of adipose tissue and its efficacy in chronic ulcers compared with conventional methods and concludes that using autOLOGous adipose-derived stromal vascular fraction cells is an effective treatment method for Chronic ulcers.
Therapeutic Effects of Human Adipose-Derived Products on Impaired Wound Healing in Irradiated Tissue
TLDR
Tissue devitalization by irradiation was dose-dependent, although fractionated protocols helped to reduce it, and fat-derived products harboring adipose-derived stem cells successfully revitalized irradiated tissues and accelerated wound healing.
A Comprehensive In Vitro Comparison of Preparation Techniques for Fat Grafting
TLDR
Property of processed lipoaspirate were influenced by the preparation procedure, however, the differences were not dramatic; both centrifugation and membrane-based filtration are methods of choice whose selection depends on other criteria for individual surgical settings.
Impact of human adipose tissue-derived stem cells on dermatofibrosarcoma protuberans cells in an indirect co-culture: an in vitro study
TLDR
It is demonstrated that ADSCs can enhance different malignant properties of DFSP cells in vitro, which should not be neglected when considering the clinical use of human ADSCs and its related derivatives in skin regenerative therapies.
...
...

References

SHOWING 1-10 OF 30 REFERENCES
Long-Term survival of fat transplants: Controlled demonstrations
TLDR
The potential lasting nature of corrections performed with the transplantation of fatty tissue and is supported by over 400 infiltrations into the nasolabial folds in the author's practice are demonstrated.
Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration
TLDR
Identification of factors that promote differentiation of the progenitor cells will permit functional incorporation into neo-vessels of specific tissues while diminishing potential toxicity to other organs.
Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells
TLDR
The findings suggest that autologous delivery of either native or transduced subcutaneous ASCs, which are regulated by hypoxia, may be a novel therapeutic option to enhance angiogenesis or achieve cardiovascular protection.
Fat grafting.
TLDR
The authors' objective is to improve the retention of the fat graft by using less traumatic methods to collect the fat, to concentrate it, and to reinject it to obtain more reliable augmentations for the cosmetic improvement of tissue defects.
Isolation of a Highly Clonogenic and Multipotential Subfraction of Adult Stem Cells from Bone Marrow Stroma
TLDR
A standardized assay by light scattering is developed to measure the content of rapidly self‐renewing cells (RS cells) in preparations of MSCs and enables us to isolate RS cells that were up to 90% clonogenic and that generated single cell–derived colonies that differentiated into either mineralizing cells or adipocytes with appropriate additions to the medium.
Adipose-derived adult stem cells: isolation, characterization, and differentiation potential.
TLDR
Adipose tissue is an abundant, accessible, and replenishable source of adult stem cells that can be isolated from liposuction waste tissue by collagenase digestion and differential centrifugation, and these ADAS cells have potential applications for the repair and regeneration of acute and chronically damaged tissues.
Comparison of Multi-Lineage Cells from Human Adipose Tissue and Bone Marrow
TLDR
This study is the first comparison of PLA cells and MSCs isolated from the same patient, and no significant differences were observed for yield of adherent stromal cells, growth kinetics, cell senescence, multi-lineage differentiation capacity, and gene transduction efficiency.
Circulation in the breast after radiotherapy and breast conservation.
TLDR
Radiotherapy after breast conservation surgery does not lead to long-term changes in basal glandular, subcutaneous, or skin circulation in the breast.
...
...