Clinical Significance of Serum S100A12 in Acute Otitis Media in Young Children

@article{Liu2012ClinicalSO,
  title={Clinical Significance of Serum S100A12 in Acute Otitis Media in Young Children},
  author={Keyi Liu and Michael E. Pichichero},
  journal={The Pediatric infectious disease journal},
  year={2012},
  volume={31 3},
  pages={e56-8}
}
BACKGROUND S100A12 is a calcium-binding protein predominantly expressed in neutrophil granulocytes in response to infections or inflammation. Acute otitis media (AOM) is a local infection mainly caused by Streptococcus pneumoniae (Spn), nontypeable Haemophilus influenzae (NTHi), and/or Moraxella catarrhalis (Mcat). METHODS To study if S100A12 values could serve as a diagnostic marker, serum S100A12 concentrations were tested in young children before, at onset, and after recovery from AOM… CONTINUE READING