Clinical Significance of Incidental Colonic 18F-FDG Uptake on PET/CT Images in Patients with Gastric Adenocarcinoma

  title={Clinical Significance of Incidental Colonic 18F-FDG Uptake on PET/CT Images in Patients with Gastric Adenocarcinoma},
  author={Jung Ho Shim and Joo Hyun O and Seong Il Oh and Han Mo Yoo and Hae Myung Jeon and Cho Hyun Park and Sung Hoon Kim and Kyo Young Song},
  journal={Journal of Gastrointestinal Surgery},
  • J. Shim, J. O, K. Song
  • Published 30 June 2012
  • Medicine
  • Journal of Gastrointestinal Surgery
Background and ObjectivesWe assessed the ability of positron emission tomography–computed tomography (PET/CT) to detect synchronous colonic pathology and determined the significance of 18F-fluorodeoxyglucose (18F-FDG) activity in the colon of gastric cancer patients.MethodsA total of 239 gastric cancer patients who underwent PET/CT and colonoscopy preoperatively were included. FDG uptake patterns on PET/CT were classified as (1) group A, focal; (2) group B, diffuse; and (3) group C, no uptake… 
Correlation between incidental focal colorectal FDG uptake on PET/CT and colonoscopic and histopathological results
Abstract Objective and aims The primary aim of this study was to evaluate the correlation between incidental focal colorectal foci on fluorodeoxyglucose positron emission tomography/computed
Relevance of Incidental Colorectal FDG-PET/CT-Enhanced Lesions
Introduction: Positron emission tomography/computed tomographies (PET/CTs) may result in incidental findings of fluorodeoxyglucose (FDG)-avid lesions in the colon. The aim of this study was to assess
Incidental colorectal FDG uptake on PET/CT scan and lesions observed during subsequent colonoscopy: a systematic review
Incidental colorectal FDG uptake, as evaluated by subsequent colonoscopy, often reveals neoplastic lesions.
Incidental detection of colorectal lesions on 18 F-FDG-PET/CT is associated with high proportion of malignancy: A study in 549 patients
The results indicate that patients with incidental colorectal FDG uptake should be referred to diagnostic work-up including colonoscopy, as it was associated with a high rate of malignant or premalignant lesions.
What approach should we take for the incidental finding of increased 18F-FDG uptake foci in the colon on PET/CT?
Colonoscopic and histopathological examination of the increased foci of colonic 18F-FDG uptake incidentally detected at PET/CT seems to be a plausible approach.
Incidental 18F-FDG uptake in the colon: value of contrast-enhanced CT correlation with colonoscopic findings
By analyzing additional morphological changes in contrast-enhanced CT imaging, the specificity of focal colonic 18F-FDG uptake for precancerous and cancerous lesions can be increased but leads to a considerate loss of sensitivity, therefore, every focal Colonic uptake should be followed up by colonoscopy.
Prevalence and malignancy risk of focal colorectal incidental uptake detected by 18F-FDG-PET or PET/CT: a meta-analysis
Meta-analyze published data about prevalence and malignancy risk of focal colorectal incidentalomas detected by Fluorine-18-Fluorodeoxyglucose positron emission tomography or positron emissions tomography/computed tomography found that SUV is not reliable as a tool to differentiate between malignant, premalignant and benign FCIs.
Investigation of Incidental Bowel FDG Uptake
A formal modelling and cost-effectiveness analysis may also be required in different health care systems with different policies for funding both FDG-PET scans and screening colonoscopies to properly justify the process.
Incidental Findings in 18 F-FDG PET/CT and PET/MR
This chapter provides an overview of the most common incidental findings in 18F-FDG PET/CT and PET/MR, followed by a brief outline of frequent findings in morphological CT that demand special attention in hybrid imaging.
Diagnostic role and limitations of 2-deoxy-2-(F-18) fluoro- D-Glucose positron emission tomography (FDG-PET) in screening of synchronous cancer of other organs in patients with head and neck cancers
The aim of the study was to evaluate the diagnostic role and limitations of pre-treatment 2-deoxy-2(F-18) Fluoro-D-Glucose Positron Emission Tomography (FDG-PET) in patients with head and neck cancer.


Incidental colonic focal lesions detected by FDG PET/CT.
The presence of a focal colonic FDG uptake incidental finding on a PET/CT scan justifies a colonoscopy to detect (pre-)malignant lesions.
Significance of incidental 18F-FDG accumulations in the gastrointestinal tract in PET/CT: correlation with endoscopic and histopathologic results.
Although IDLs of the GIT on partial-body PET/CT scans are found in about 3% of cases, they are associated with a substantial risk of an underlying cancerous or precancerous lesion and early identification of these occult lesions may have a major impact on the patients' management and outcome.
Incidental Detection of Colon Cancer by FDG Positron Emission Tomography in Patients Examined for Pulmonary Nodules
The routine use of FDG PET to characterize lung lesions significantly increases the probability of detecting unexpected extrathoracic disease and in these patients, the incidental finding of colon cancer had an important effect on their treatment and may prove to be very cost-effective.
PET/CT detection of unexpected gastrointestinal foci of 18F-FDG uptake: incidence, localization patterns, and clinical significance.
Investigational focal (18)F-FDG uptake localized by PET/CT within the GIT is of clinical significance in most patients and should be followed up with appropriate invasive procedures guided by hybrid imaging results.
18F-FDG PET detection of colonic adenomas.
Increased glucose metabolism is observed in colonic adenomas, and detectability with PET increases with the increase in adenoma size, according to a retrospective study of 110 subjects who underwent both PET study and total colonoscopy.
Accuracy of FDG-PET in Gastric Cancer. Preliminary Experience.
Assessment of lymph node metastases using 18F-FDG PET in patients with advanced gastric cancer
FDG PET exhibits good specificity for LN staging of gastric cancer, and FDG uptake in the primary tumour is significantly related to the accuracy of FDG PET, despite some clear limitations.
Colonic adenoma detected by positron emission tomography (PET): a case report.
The findings in this case suggest that increased glucose metabolism can be depicted by PET in colonic adenoma as well as in primary colonic carcinoma, and it is noteworthy that PET can be used in the detection of adenomas.
2-(18F)-fluoro-2-deoxy-D-glucose positron emission tomography detects clinical relevant adenomas of the colon: a prospective study.
Investigating whether FDG-PET is able to detect colonic adenomas found that the diagnostic test characteristics improve with size and grade of dysplasia of the adenoma.
Is 18F-FDG PET/CT useful for imaging and management of patients with suspected occult recurrence of cancer?
  • O. Israel, M. Mor, R. Epelbaum
  • Medicine
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 2004
It is indicated that PET/CT may improve the accuracy of occult cancer detection and further lead to management changes in patients with increasing levels of tumor markers as the sole suspicion of recurrent malignancy.