Clinical Significance of Incidental Colonic 18F-FDG Uptake on PET/CT Images in Patients with Gastric Adenocarcinoma

@article{Shim2012ClinicalSO,
  title={Clinical Significance of Incidental Colonic 18F-FDG Uptake on PET/CT Images in Patients with Gastric Adenocarcinoma},
  author={Jung Ho Shim and Joo Hyun O and Seong Il Oh and Han Mo Yoo and Hae Myung Jeon and Cho Hyun Park and Sung Hoon Kim and Kyo Young Song},
  journal={Journal of Gastrointestinal Surgery},
  year={2012},
  volume={16},
  pages={1847-1853}
}
  • J. Shim, J. O, K. Song
  • Published 30 June 2012
  • Medicine
  • Journal of Gastrointestinal Surgery
Background and ObjectivesWe assessed the ability of positron emission tomography–computed tomography (PET/CT) to detect synchronous colonic pathology and determined the significance of 18F-fluorodeoxyglucose (18F-FDG) activity in the colon of gastric cancer patients.MethodsA total of 239 gastric cancer patients who underwent PET/CT and colonoscopy preoperatively were included. FDG uptake patterns on PET/CT were classified as (1) group A, focal; (2) group B, diffuse; and (3) group C, no uptake… 
Correlation between incidental focal colorectal FDG uptake on PET/CT and colonoscopic and histopathological results
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Relevance of Incidental Colorectal FDG-PET/CT-Enhanced Lesions
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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Incidental Findings in 18 F-FDG PET/CT and PET/MR
TLDR
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Diagnostic role and limitations of 2-deoxy-2-(F-18) fluoro- D-Glucose positron emission tomography (FDG-PET) in screening of synchronous cancer of other organs in patients with head and neck cancers
TLDR
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References

SHOWING 1-10 OF 31 REFERENCES
Incidental colonic focal lesions detected by FDG PET/CT.
TLDR
The presence of a focal colonic FDG uptake incidental finding on a PET/CT scan justifies a colonoscopy to detect (pre-)malignant lesions.
Significance of incidental 18F-FDG accumulations in the gastrointestinal tract in PET/CT: correlation with endoscopic and histopathologic results.
TLDR
Although IDLs of the GIT on partial-body PET/CT scans are found in about 3% of cases, they are associated with a substantial risk of an underlying cancerous or precancerous lesion and early identification of these occult lesions may have a major impact on the patients' management and outcome.
Incidental Detection of Colon Cancer by FDG Positron Emission Tomography in Patients Examined for Pulmonary Nodules
TLDR
The routine use of FDG PET to characterize lung lesions significantly increases the probability of detecting unexpected extrathoracic disease and in these patients, the incidental finding of colon cancer had an important effect on their treatment and may prove to be very cost-effective.
PET/CT detection of unexpected gastrointestinal foci of 18F-FDG uptake: incidence, localization patterns, and clinical significance.
TLDR
Investigational focal (18)F-FDG uptake localized by PET/CT within the GIT is of clinical significance in most patients and should be followed up with appropriate invasive procedures guided by hybrid imaging results.
18F-FDG PET detection of colonic adenomas.
TLDR
Increased glucose metabolism is observed in colonic adenomas, and detectability with PET increases with the increase in adenoma size, according to a retrospective study of 110 subjects who underwent both PET study and total colonoscopy.
Accuracy of FDG-PET in Gastric Cancer. Preliminary Experience.
Assessment of lymph node metastases using 18F-FDG PET in patients with advanced gastric cancer
TLDR
FDG PET exhibits good specificity for LN staging of gastric cancer, and FDG uptake in the primary tumour is significantly related to the accuracy of FDG PET, despite some clear limitations.
Colonic adenoma detected by positron emission tomography (PET): a case report.
TLDR
The findings in this case suggest that increased glucose metabolism can be depicted by PET in colonic adenoma as well as in primary colonic carcinoma, and it is noteworthy that PET can be used in the detection of adenomas.
2-(18F)-fluoro-2-deoxy-D-glucose positron emission tomography detects clinical relevant adenomas of the colon: a prospective study.
TLDR
Investigating whether FDG-PET is able to detect colonic adenomas found that the diagnostic test characteristics improve with size and grade of dysplasia of the adenoma.
Is 18F-FDG PET/CT useful for imaging and management of patients with suspected occult recurrence of cancer?
  • O. Israel, M. Mor, R. Epelbaum
  • Medicine
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 2004
TLDR
It is indicated that PET/CT may improve the accuracy of occult cancer detection and further lead to management changes in patients with increasing levels of tumor markers as the sole suspicion of recurrent malignancy.
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