Clinical Significance of Androgen Receptor Splice Variant-7 mRNA Detection in Circulating Tumor Cells of Men With Metastatic Castration-Resistant Prostate Cancer Treated With First- and Second-Line Abiraterone and Enzalutamide.

@article{Antonarakis2017ClinicalSO,
  title={Clinical Significance of Androgen Receptor Splice Variant-7 mRNA Detection in Circulating Tumor Cells of Men With Metastatic Castration-Resistant Prostate Cancer Treated With First- and Second-Line Abiraterone and Enzalutamide.},
  author={Emmanuel S Antonarakis and Changxue Lu and Brandon S. Luber and Hao Wang and Yan Chen and Yezi Zhu and John L. Silberstein and Maritza N Taylor and Benjamin L. Maughan and Samuel R Denmeade and Kenneth J. Pienta and Channing J Paller and Michael Anthony Carducci and Mario A. Eisenberger and Jun Luo},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2017},
  volume={35 19},
  pages={
          2149-2156
        }
}
Purpose We reported previously that the detection of androgen receptor splice variant-7 (AR-V7) mRNA in circulating tumor cells (CTCs) correlated with poor outcomes from the use of abiraterone and enzalutamide in patients with castration-resistant prostate cancer (CRPC). Here, we expanded our cohort size to better characterize the prognostic significance of AR-V7 in this setting. Methods We prospectively enrolled 202 patients with CRPC starting abiraterone or enzalutamide and investigated the… CONTINUE READING
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