Clinical Responses in a Phase II Study Using Adoptive Transfer of Short-term Cultured Tumor Infiltration Lymphocytes in Metastatic Melanoma Patients

@article{Besser2010ClinicalRI,
  title={Clinical Responses in a Phase II Study Using Adoptive Transfer of Short-term Cultured Tumor Infiltration Lymphocytes in Metastatic Melanoma Patients},
  author={M. Besser and R. Shapira-Frommer and A. Treves and D. Zippel and O. Itzhaki and Liat Hershkovitz and Daphna Levy and A. Kubi and E. Hovav and Natalia Chermoshniuk and B. Shalmon and I. Hardan and R. Catane and G. Markel and S. Apter and A. Ben-nun and I. Kuchuk and A. Shimoni and A. Nagler and J. Schachter},
  journal={Clinical Cancer Research},
  year={2010},
  volume={16},
  pages={2646 - 2655}
}
Purpose: Adoptive cell therapy with autologous tumor-infiltrating lymphocytes (TIL) has shown promising results in metastatic melanoma patients. Although objective response rates of over 50% have been reported, disadvantages of this approach are the labor-intensive TIL production and a very high drop-out rate of enrolled patients, limiting its widespread applicability. Previous studies showed a clear correlation between short TIL culture periods and clinical response. Therefore, we used a new… Expand
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A phase I clinical trial combining dendritic cell vaccination with adoptive T cell transfer in patients with stage IV melanoma
Adoptive T-cell transfer in melanoma.
Focus on Adoptive T Cell Transfer Trials in Melanoma
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