Clinical Relevance of Fascial Tissue and Dysfunctions

  title={Clinical Relevance of Fascial Tissue and Dysfunctions},
  author={Werner Klingler and Martina Velders and Kerstin Hoppe and M Pedro and Robert Schleip},
  journal={Current Pain and Headache Reports},
Fascia is composed of collagenous connective tissue surrounding and interpenetrating skeletal muscle, joints, organs, nerves, and vascular beds. Fascial tissue forms a whole-body, continuous three-dimensional viscoelastic matrix of structural support. The classical concept of its mere passive role in force transmission has recently been disproven. Fascial tissue contains contractile elements enabling a modulating role in force generation and also mechanosensory fine-tuning. This hypothesis is… 
Active contractile properties of fascia
The current understanding of fascial stiffness regulation is highlighted and the common clear distinction between active tissues and passive tissues in musculoskeletal dynamics is questioned.
The interplay between fascia, skeletal muscle, nerves, adipose tissue, inflammation and mechanical stress in musculo-fascial regeneration
It is hypothesised, for the first time, that for effective regeneration of skeletal muscle, both muscle and fascial tissues are necessary, and that nervous and adipose tissues contribute and deeply influence this process.
Morphological features of fascia lata in relation to fascia diseases
The main cells found were fibroblasts, fibrocytes, mast cells, cells showing myoid differentiation, nerve cells, and most interestingly, telocytes, which may contribute to a better understanding of the pathogenesis of fascial disorders and improve fascia lata application as a graft material.
Fascia Is Able to Actively Contract and May Thereby Influence Musculoskeletal Dynamics: A Histochemical and Mechanographic Investigation
Tension of myofascial tissue is actively regulated by myofibroblasts with the potential to impact active musculoskeletal dynamics.
Clinical Insights into the Importance of Scars and Scar Release in Paediatric Chronic Myofascial Pain
Emphasis is placed on the fundamental need to assess scar history and scar characteristics to determine if scars should be treated as a component of multidisciplinary chronic pain management.
Hyaluronan and the Fascial Frontier
From fasciacytes to chronic pain, this review aims to highlight the connections between HA and fascial health.
Myofascia - the unexplored tissue: Myofascial kinetic lines in horses, a model for describing locomotion using comparative dissection studies derived from human lines
It is concluded that the lines described in this study form the basis of a readily use-able tool that can be applied by practitioners to track the main cause of locomotory problems in horses afflicted with impaired performance.
Molecular Mechanisms Underlying the Pain-Relieving Effects of Extracorporeal Shock Wave Therapy: A Focus on Fascia Nociceptors
The findings discussed in the present review are supposed to add novel viewpoints that may further enrich knowledge on the complex interactions occurring between disorders of the deep fascia including changes in innervation, sensitization of fascial nociceptors, the pathophysiology of chronic musculoskeletal pain of MPS, and EWST-induced analgesia.
Functional in vitro tension measurements of fascial tissue – a novel modified superfusion approach
The modified superfusion method may improve force registrations of slow contracting fascial tissue and minimize artefacts of fluid application after demonstrating pharmacologically induced contractile responses in lumbar fascia samples.
Manipulation of the Fascial System Applied During Acute Inflammation of the Connective Tissue of the Thoracolumbar Region Affects Transforming Growth Factor-β1 and Interleukin-4 Levels: Experimental Study in Mice
MFS may have an anti-inflammatory effect, based on TGF-β1 and IL-4, which may have inhibited neutrophil migration and lower levels of NOS-2 may be linked to the lack of macrophages, which is responsible for Nos-2 expression.


Substantial effects of epimuscular myofascial force transmission on muscular mechanics have major implications on spastic muscle and remedial surgery.
  • C. Yucesoy, P. Huijing
  • Biology
    Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology
  • 2007
Fascial Components of the Myofascial Pain Syndrome
Recent developments in the biology of fascia, and in particular, its associated hyaluronan (HA)-rich matrix that address the issue of MPS are summarized.
The role of fibrosis in Duchenne muscular dystrophy
Interestingly, an increase in endomysial tissue is apparent long before any muscular degeneration can be observed, and several avenues are discussed in terms of potential antifibrotic therapy approaches.
Reduced thoracolumbar fascia shear strain in human chronic low back pain
Thoracolumbar fascia shear strain was reduced in the LBP group compared with the No-LBP group and this reduction of shear plane motion may be due to abnormal trunk movement patterns and/or intrinsic connective tissue pathology.
Layers of the abdominal wall: anatomical investigation of subcutaneous tissue and superficial fascia
The term “superficial fascia” should only be used as a synonym for the membranous layer in order to investigate the structure of abdominal subcutaneous tissue, macroscopic and microscopic analyses of its layers were performed in fresh cadavers.