Clinical Pharmacy: Case Studies

@inproceedings{McCarron1974ClinicalPC,
  title={Clinical Pharmacy: Case Studies},
  author={Margaret M. McCarron and Ben J. Devine},
  year={1974}
}
This series of case studies has been prepared by the faculty of the Department of Clinical Education and Services at U.S.C. School of Pharmacy as a continuing education course for pharmacists. The cases are meant to be studied in sequence; concepts and laboratory test evaluations presented in one case will be used in subsequent cases. All normal laboratory test values will be those used at the Los Angeles County/U.S.C. Medical Center; values may differ at other hospitals depending on the method… 

Figures from this paper

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  • Alexandra P PunkeJ. Waddell
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Assessment of renal function in clinical practice at the bedside of burn patients.

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Some of the principles required to optimize antimicrobial dosing are discussed and recently obtained data regarding its application to the critically ill patient is discussed.

A pre–postintervention study to evaluate the impact of dose calculators on the accuracy of gentamicin and vancomycin initial doses

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Dosing of medications in morbidly obese patients in the intensive care unit setting

There is a paucity of data upon which to make recommendations for dosing commonly used medications in the morbidly obese patient in the ICU, although recommendations were provided based on the available information.
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References

SHOWING 1-10 OF 21 REFERENCES

Dosage of gentamicin for pseudomonas infections.

Since acceptance on the obstetric list for new applicants is now almost entirely confined to those with postgraduate obstetric experience, it is clear that the future general-practitioner maternity service will show an increasing proportion of general- Practitioner obstetricians with special interest and skill.

Renal insufficiency associated with gentamicin therapy.

The results suggest that all patients treated with gentamicin deserve more adequate monitoring of renal function and point out the need for large scale studies to identify those patients with the greatest risk of nephrotoxicity.

Ototoxicity of gentamicin in man: a survey and controlled analysis of clinical experience in the United States.

The risk of ototoxicity should not prevent proper treatment with gentamicin and the dose (in mg/kg per day) was the major factor in treatment and the only significant one in patients with normal renal function.

Parenteral administration of gentamicin in renal failure: patients undergoing intermittent haemodialysis.

Thus in normal subjects or patients with impaired renal function injection of 40 mg. of gentamicin fails in the majority of cases to produce serum levels reaching the minimum inhibitory concentration

Possible nephrotoxicity of gentamicin.

Although clinical evidence suggests that Gentamicin adversely effects the kidneys, the nephrotoxicity of gentamicin could not be reproduced in experiments and a common physiologic setting or interaction of drugs that might contribute to the renal failure was defined.

Elimination of tritiated gentamicin in normal human subjects and in patients with severely impaired renal function

Evidence is presented that a certain amount of intravenously administered gentamicin is excreted as a coniugated metabolite, and Pharmacokinetic considerations indicate that usage of such nomograms in patients with moderately reduced or normal renal function may lead to inadequate serum concentrations of the drug.

GENTAMICIN SULFATE, NEW ANTIBIOTIC AGAINST GRAM-NEGATIVE BACILLI. LABORATORY, PHARMACOLOGICAL, AND CLINICAL EVALUATION.

A laboratory and clinical evaluation was made of gentamicin sulfate which is a new antibiotic produced by a species of the genus Micromonospora . It has a broad spectrum that includes both

Correlation of serum creatinine concentration and gentamicin half-life.

Kinetic analysis predicts that repetition of this loading dose every third half-life will result in therapeutic, nontoxic serum levels in patients with renal failure and an alternate approach using a constant dose interval but varying the quantity of drug can be predicted from a nomogram.

Nephrotoxicity of aminoglycosides and gentamicin.

Gentamicin is a new antibiotic in a category with the aminoglycoside antibiotics kanamycin and neomycin as well as streptomycin, colistimethate and polymyxin B. For this reason its potential toxicity