Clinical Pharmacy: Case Studies

  title={Clinical Pharmacy: Case Studies},
  author={M M McCarron and Ben J. Devine},
This series of case studies has been prepared by the faculty of the Department of Clinical Education and Services at U.S.C. School of Pharmacy as a continuing education course for pharmacists. The cases are meant to be studied in sequence; concepts and laboratory test evaluations presented in one case will be used in subsequent cases. All normal laboratory test values will be those used at the Los Angeles County/U.S.C. Medical Center; values may differ at other hospitals depending on the method… 

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Gentamicin and Tobramycin Dosing Guidelines: An Evaluation

The goal is to promote consistent interpretation and application of clinical and kinetic data by the members of the aminoglycoside dosing service to provide a structured yet adaptive approach to the clinical use of gentamicin and tobramycin.

Improving dosing of gentamicin in the obese patient: a 3-cycle drug chart and case note audit

Online tools can be used to improve prescribing for the complex dosing policies that will increasingly been required to tailor prescribing in obese patients and turnaround time of blood sampling to dose delivery in an NHS hospital is assessed.

Creation and evaluation of a cancer chemotherapy order review guide for use at a community hospital

  • Alexandra P PunkeJ. A. Waddell
  • Medicine
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
  • 2019
A step-by-step chemotherapy order evaluation guide with a detailed explanation for each step was created to evaluate non-oncology trained pharmacists' ability to accurately review simulated chemotherapy orders post-education using the guide.

Assessment of renal function in clinical practice at the bedside of burn patients.

Renal function was assessed using serum creatinine, 24 h urinary CL(CR), and the Cockcroft-Gault, Robert, Kirkpatrick and simplified MDRD equations and it was shown that the formulae currently used to calculate creat inine clearance on the basis of serum creatInine are inadequate for use in burn patients, and they should be abandoned in favour of direct measurement from a 24 h urine collection.

Basic elements of applied pharmacology in the intensive care unit

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Evaluation of a Digoxin Pharmacokinetic Monitoring Service in a Community Hospital

Clinical pharmacist intervention was found to be associated with significant changes in patient outcomes, including length of stay and morbidity, and the cost of the PKS was offset by savings resulting from the reduction in digoxin assays alone.

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Some of the principles required to optimize antimicrobial dosing are discussed and recently obtained data regarding its application to the critically ill patient is discussed.

Appropriate use of heparin. Empiric vs nomogram-based dosing.

Use of a weight-based nomogram to determine the initial and maintenance heparin infusion rates was associated with a higher percentage of patients admitted to the cardiology service reaching the targeted therapeutic APTT range at a time earlier in the course of therapy compared with empiric dosing.

A pre–postintervention study to evaluate the impact of dose calculators on the accuracy of gentamicin and vancomycin initial doses

It is suggested that gentamicin and vancomycin dose calculators significantly improved the prescribing of initial doses of these agents, and healthcare organisations should consider using such CDS tools to support the prescribe of these high-risk drugs.

Dosing of medications in morbidly obese patients in the intensive care unit setting

There is a paucity of data upon which to make recommendations for dosing commonly used medications in the morbidly obese patient in the ICU, although recommendations were provided based on the available information.



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Renal insufficiency associated with gentamicin therapy.

The results suggest that all patients treated with gentamicin deserve more adequate monitoring of renal function and point out the need for large scale studies to identify those patients with the greatest risk of nephrotoxicity.

Ototoxicity of gentamicin in man: a survey and controlled analysis of clinical experience in the United States.

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Abstract Gentamicin has been given to patients with compromised renal function or severe renal failure, in toxic or nearly toxic peak serum concentrations followed by long periods of subinhibitory ...

Creatinine Clearance: Bedside Estimate

The objective was to establish an experimental procedure and show direct AFM measurements that unequivocally can be assigned as a baseline for the determination of creatinine clearance by the immune system.