Clinical Pharmacy: Case Studies

@inproceedings{McCarron1974ClinicalPC,
  title={Clinical Pharmacy: Case Studies},
  author={M M McCarron and Ben J. Devine},
  year={1974}
}
This series of case studies has been prepared by the faculty of the Department of Clinical Education and Services at U.S.C. School of Pharmacy as a continuing education course for pharmacists. The cases are meant to be studied in sequence; concepts and laboratory test evaluations presented in one case will be used in subsequent cases. All normal laboratory test values will be those used at the Los Angeles County/U.S.C. Medical Center; values may differ at other hospitals depending on the method… 

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Dosing of medications in morbidly obese patients in the intensive care unit setting

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References

SHOWING 1-10 OF 21 REFERENCES

Dosage of gentamicin for pseudomonas infections.

Since acceptance on the obstetric list for new applicants is now almost entirely confined to those with postgraduate obstetric experience, it is clear that the future general-practitioner maternity service will show an increasing proportion of general- Practitioner obstetricians with special interest and skill.

Renal insufficiency associated with gentamicin therapy.

The results suggest that all patients treated with gentamicin deserve more adequate monitoring of renal function and point out the need for large scale studies to identify those patients with the greatest risk of nephrotoxicity.

Ototoxicity of gentamicin in man: a survey and controlled analysis of clinical experience in the United States.

The risk of ototoxicity should not prevent proper treatment with gentamicin and the dose (in mg/kg per day) was the major factor in treatment and the only significant one in patients with normal renal function.

Elimination of tritiated gentamicin in normal human subjects and in patients with severely impaired renal function

Evidence is presented that a certain amount of intravenously administered gentamicin is excreted as a coniugated metabolite, and Pharmacokinetic considerations indicate that usage of such nomograms in patients with moderately reduced or normal renal function may lead to inadequate serum concentrations of the drug.

GENTAMICIN SULFATE, NEW ANTIBIOTIC AGAINST GRAM-NEGATIVE BACILLI. LABORATORY, PHARMACOLOGICAL, AND CLINICAL EVALUATION.

A laboratory and clinical evaluation was made of gentamicin sulfate which is a new antibiotic produced by a species of the genus Micromonospora . It has a broad spectrum that includes both

Nephrotoxicity of aminoglycosides and gentamicin.

Gentamicin is a new antibiotic in a category with the aminoglycoside antibiotics kanamycin and neomycin as well as streptomycin, colistimethate and polymyxin B. For this reason its potential toxicity

Gentamicin therapy in renal failure: a nomogram for dosage.

Abstract Gentamicin has been given to patients with compromised renal function or severe renal failure, in toxic or nearly toxic peak serum concentrations followed by long periods of subinhibitory ...

Creatinine Clearance: Bedside Estimate

The objective was to establish an experimental procedure and show direct AFM measurements that unequivocally can be assigned as a baseline for the determination of creatinine clearance by the immune system.