Clinical Pharmacology of Propofol: An Intravenous Anesthetic Agent

@inproceedings{Larijani1989ClinicalPO,
  title={Clinical Pharmacology of Propofol: An Intravenous Anesthetic Agent},
  author={G. Larijani and I. Gratz and M. Afshar and A. G. Jacobi},
  booktitle={DICP : the annals of pharmacotherapy},
  year={1989}
}
  • G. Larijani, I. Gratz, +1 author A. G. Jacobi
  • Published in
    DICP : the annals of…
    1989
  • Medicine
  • Propofol is a 2,6-diisopropylphenol with sedative-hypnotic properties. Because of its slight solubility in water, the drug is formulated as an emulsion for clinical use. It is highly lipophilic and distributes extensively in the body. The blood concentration-time profile of propofol after an iv bolus injection follows a three-compartment model with half-lives of 2–4 min, 30–45 min, and 3–63 h, respectively. Propofol is extensively metabolized by the liver prior to its elimination by the kidney… CONTINUE READING

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