Clinical Pharmacology of Propofol: An Intravenous Anesthetic Agent

@inproceedings{Larijani1989ClinicalPO,
  title={Clinical Pharmacology of Propofol: An Intravenous Anesthetic Agent},
  author={Ghassem E. Larijani and Irwin L. Gratz and Maryam Afshar and Athole G. McNeil Jacobi},
  booktitle={DICP : the annals of pharmacotherapy},
  year={1989}
}
Propofol is a 2,6-diisopropylphenol with sedative-hypnotic properties. Because of its slight solubility in water, the drug is formulated as an emulsion for clinical use. It is highly lipophilic and distributes extensively in the body. The blood concentration-time profile of propofol after an iv bolus injection follows a three-compartment model with half-lives of 2–4 min, 30–45 min, and 3–63 h, respectively. Propofol is extensively metabolized by the liver prior to its elimination by the kidney… 

Tables from this paper

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TLDR
There is a good correlation between the blood concentration of propofol and the pharmacodynamic responses during recovery and a shift to the left of the concentration-effect curve in regard to drowsiness and a statistically significant prolongation of recovery by CFF-measurement which suggests a possible dynamic interaction with alfentanil.
Effect of propofol titration v/s bolus during induction of anesthesia on hemodynamics and bispectral index.
TLDR
Titration of Propofol reduces hemodynamic changes, dose requirement and is able to achieve same level of BIS as in bolus as well as reducing the dose requirement.
Reduction by Fentanyl of the Cp50 Values of Propofol and Hemodynamic Responses to Various Noxious Stimuli
TLDR
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TLDR
Stress and haemodynamic responses were better controlled using TIVA than desflurane inhalation added to a subanaesthetic dose of propofol in patients undergoing CABG.
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It is suggested that a BIS-guided compared to a weight-adjusted manual administration of propofol for induction of general anesthesia in non-geriatric patients will not lower the incidence and degree of arterial hypotension.
The effect of propofol when injected at different speeds for induction of general anesthesia: an observational study
TLDR
Induction dose required for loss of consciousness increased with a faster rate of infusion while time for induction was shorter in P800 compared to P400 and P600, and the decrease in mean blood pressure was less after induction in P400.
In vitro effects of propofol on gravid human myometrium.
TLDR
The results of this study show that propofol decreases isolated human uterine muscle contractility in a dose-dependent manner.
In vitro effects of propofol on gravid human myometrium.
TLDR
The results of this study show that propofol decreases isolated human uterine muscle contractility in a dose-dependent manner.
THE EFFECT OF PROPOFOL ON THE CANINE
TLDR
The results suggest that propofol in low doses may be useful for sedation during Sphincter ofOddi manometry in humans, and further studies of the effects of prop ofol on the human sphincte of Oddi are warranted.
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TLDR
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