Clinical Pharmacology of Opioids for Pain

@article{Inturrisi2002ClinicalPO,
  title={Clinical Pharmacology of Opioids for Pain},
  author={Charles E Inturrisi},
  journal={The Clinical Journal of Pain},
  year={2002},
  volume={18},
  pages={S3-S13}
}
  • C. Inturrisi
  • Published 1 July 2002
  • Biology, Medicine
  • The Clinical Journal of Pain
The pharmacological effects of the opioid analgesics are derived from their complex interactions with three opioid receptor types (μ, δ, and κ; morphine is an agonist at the μ opioid receptor). These receptors are found in the periphery, at presynaptic and postsynaptic sites in the spinal cord dorsal horn, and in the brain stem, thalamus, and cortex, in what constitutes the ascending pain transmission system, as well as structures that comprise a descending inhibitory system that modulates pain… 
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