Clinical Pharmacology of Omeprazole

@article{Howden1991ClinicalPO,
  title={Clinical Pharmacology of Omeprazole},
  author={C. Howden},
  journal={Clinical Pharmacokinetics},
  year={1991},
  volume={20},
  pages={38-49}
}
  • C. Howden
  • Published 1991
  • Medicine
  • Clinical Pharmacokinetics
  • SummaryOmeprazole is a specific inhibitor of H+, K+-ATPase or ‘proton pump’ in parietal cells. This enzyme is responsible for the final step in the process of acid secretion; omeprazole blocks acid secretion in response to all stimuli. Single doses produce dose-dependent inhibition with increasing effect over the first few days, reaching a maximum after about 5 days. Doses of omeprazole 20mg daily or greater are able to virtually abolish intragastric acidity in most individuals, although lower… CONTINUE READING

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