Clinical Pharmacology of Omeprazole

@article{Howden1991ClinicalPO,
  title={Clinical Pharmacology of Omeprazole},
  author={C. Howden},
  journal={Clinical Pharmacokinetics},
  year={1991},
  volume={20},
  pages={38-49}
}
  • C. Howden
  • Published 1991
  • Medicine
  • Clinical Pharmacokinetics
SummaryOmeprazole is a specific inhibitor of H+, K+-ATPase or ‘proton pump’ in parietal cells. This enzyme is responsible for the final step in the process of acid secretion; omeprazole blocks acid secretion in response to all stimuli. Single doses produce dose-dependent inhibition with increasing effect over the first few days, reaching a maximum after about 5 days. Doses of omeprazole 20mg daily or greater are able to virtually abolish intragastric acidity in most individuals, although lower… Expand
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References

SHOWING 1-10 OF 62 REFERENCES
Omeprazole: pharmacokinetics and metabolism in man.
  • 110
Omeprazole: mode of action and effect on acid secretion in animals.
  • B. Wallmark
  • Chemistry, Medicine
  • Methods and findings in experimental and clinical pharmacology
  • 1989
  • 35
Omeprazole: effects on oxidative drug metabolism.
  • 51
No effect of omeprazole-induced hypoacidity on the bioavailability of amoxycillin or bacampicillin.
  • 23
Antisecretory effect and oral pharmacokinetics following low dose omeprazole in man.
  • 22
Pharmacokinetics and metabolism of omeprazole in man.
  • C. Regårdh
  • Medicine
  • Scandinavian journal of gastroenterology. Supplement
  • 1986
  • 63
...
1
2
3
4
5
...