Clinical Pharmacology of Loop Diuretics

@article{Brater2012ClinicalPO,
  title={Clinical Pharmacology of Loop Diuretics},
  author={Dr D. Craig Brater},
  journal={Drugs},
  year={2012},
  volume={41},
  pages={14-22}
}
  • D. Brater
  • Published 2012
  • Biology, Medicine
  • Drugs
SummaryThe clinical pharmacology of torasemide, bumetanide, piretanide and furosemide (frusemide) is discussed. These drugs share a similar mechanism of action in inhibiting Na+-K+-2Cl− reabsorption at the thick ascending limb of the loop of Henle. They differ in their routes of metabolism, pharmacokinetics, and potency. Whether such differences are clinically important requires further study. Bumetanide and torasemide are metabolised by cytochrome P450 pathways, whereas furosemide is… 
Clinical Pharmacology of the Loop Diuretics Furosemide and Bumetanide in Neonates and Infants
TLDR
Comparison of continuous infusion versus intermittent infusion of furosemide showed that the diuresis is more controlled with fewer hemodynamic and electrolytic variations during continuous infusion, and the risk of failure of patent ductus arteriosus closure when indomethacin or ibuprofen have been co-administered is reduced.
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TLDR
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TLDR
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Hydrochlorothiazide does not increase furosemide's effects in end-stage renal disease
TLDR
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Use of Diuretics in Chronic Kidney Disease Patients
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TLDR
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Sodium and Fluid Excretion With Torsemide in Healthy Subjects is Limited by the Short Duration of Diuretic Action
TLDR
Torsemide ER prolongs urine drug levels, thereby increasing the time spent with effective drug concentrations, reduces postdiuretic Na+ retention, and moderates a fall in glomerular filtration rate, which limits salt loss with loop diuretics.
Population Pharmacokinetic (Pop-PK) Analysis of Torsemide in Healthy Korean Males Considering CYP2C9 and OATP1B1 Genetic Polymorphisms
TLDR
The torsemide PK variability between individuals was largely explained and, in the future, individualized effective drug therapy of torSemide taking individual patient’s genotypes into account might become possible.
Safety and Efficacy of Adding Dapagliflozin to Furosemide in Type 2 Diabetic Patients With Decompensated Heart Failure and Reduced Ejection Fraction
TLDR
Dapagliflozin may provide a new drug option in the treatment of heart failure especially among vulnerable group of diabetics as it had no remarkable effects on serum potassium level and kidney functions.
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