Clinical Pharmacology of Cyclophosphamide and Ifosfamide

  title={Clinical Pharmacology of Cyclophosphamide and Ifosfamide},
  author={Jing Zhang and Quan Tian and Shu-Feng Zhou},
The oxazaphosphorine cyclophosphamide (CPA) and ifosfamide (IFO) are two commonly used DNAalkylating agents in cancer chemotherapy. This review highlights the pharmacokinetics and pharmacodynamics of the two important agents. As alkylating agents, CPA and IFO are usually combined with other anticancer drugs in the chemotherapy of solid tumors and hematological malignancies to obtain synergistic or additive anticancer effect due to complementary mechanism of action. Both compounds are prodrugs… CONTINUE READING


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