Clinical Pharmacology of Citrus bergamia: A Systematic Review

@article{Mannucci2017ClinicalPO,
  title={Clinical Pharmacology of Citrus bergamia: A Systematic Review},
  author={Carmen Mannucci and Michele Navarra and Fabrizio Calapai and Raffaele Squeri and Sebastiano Gangemi and Gioacchino Calapai},
  journal={Phytotherapy Research},
  year={2017},
  volume={31},
  pages={27 - 39}
}
Citrus bergamia Risso et Poiteau (“Bergamot”) originated from the Mediterranean ecoregion (southern Italy, Calabria). Bergamot essential oil (BEO) is used in perfumes, cosmetics, and for stress reduction. Juice from C. bergamia has been used for hyperlipidemia. We evaluated literature published on C. bergamia clinical applications. Clinical trials on C. bergamia not combined with other substances, published in English, were searched. We selected ten articles, six describing BEO effects on… 
Clinical application of bergamot (Citrus bergamia) for reducing high cholesterol and cardiovascular disease markers.
TLDR
The bergamot is a citrus fruit native to southern Italy with traditional uses that include improving immune response and cardiovascular function and their effectiveness in reducing total cholesterol and LDL cholesterol in patients with hypercholesterolemia is reported.
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TLDR
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TLDR
Preliminary evidence of the efficacy and safety of bergamot essential oil inhalation on mental well‐being in a mental health treatment center is provided, suggesting that b Bergamotessential oil aromatherapy can be an effective adjunct treatment to improve individuals' mental health and well-being.
Hypolipaemic nutraceutics: red yeast rice and Armolipid, berberine and bergamot.
TLDR
Red yeast rice products and Armolipid may be used as an alternative treatment in statin intolerant patients, especially in combination with ezetimibe and the opinion of experts on berberine and bergamot is ambiguous.
Analgesic Potential of Monoterpenes from Citrus Essential Oils
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Efficacy of bergamot: From anti‐inflammatory and anti‐oxidative mechanisms to clinical applications as preventive agent for cardiovascular morbidity, skin diseases, and mood alterations
TLDR
Compared to baseline, BE topical application and BEO aromatherapy reduce blood diastolic and systolic pressure and could have a significant effect on improving mental conditions.
Characterization and Purification of Bergamottin from Citrus grandis (L.) Osbeck cv. Yongjiazaoxiangyou and Its Antiproliferative Activity and Effect on Glucose Consumption in HepG2 cells
TLDR
Bergamottin showed significant antiproliferative activity on three cancer cell lines, i.e., human liver cancer HepG2, promyelocytic leukemia HL-60, and gastric cancer BGC-823 cells, which is the first report of its potential in anti-diabetes applications.
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TLDR
Clinical studies on the therapeutic applications of BEO exclusively focus on the field of aromatherapy, suggesting that its use can be useful for reducing anxiety and stress.
Hypolipidemic effects of Citrus bergamia Risso et Poiteau juice in rats fed a hypercholesterolemic diet.
TLDR
Results suggest that the positive intake of C. bergamia may reduce the risk of some cardiovascular diseases through its radical scavenging function and hypocholesterolemic action.
Study on the chemical composition variability of some processed bergamot (Citrus bergamia) essential oils
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TLDR
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