Clinical Pharmacology of Caffeine Citrate in Preterm Infants

  title={Clinical Pharmacology of Caffeine Citrate in Preterm Infants},
  author={Gian Maria Pacifici},
BACKGROUND: Apnea of prematurity consists in 15 to 20 sec. of breathing cessation and is the most important disorder in the control of breathing in preterm infants. It is treated with caffeine citrate. OBJECTIVES: The objectives of this article are to review: (1) the mechanisms of action, (2) the effects, (3) the metabolism, (4) the pharmacokinetics, and (5) the adverse effects of caffeine citrate in preterms. METHODS: The bibliographic search was performed using PubMed and EMBASE databases as… CONTINUE READING