Clinical Pharmacology of Atracurium Besylate (BW 33A): A New Non‐depolarizing Muscle Relaxant

  title={Clinical Pharmacology of Atracurium Besylate (BW 33A): A New Non‐depolarizing Muscle Relaxant},
  author={S. Basta and H. Ali and J. Savarese and N. Sunder and M. Gionfriddo and G. Cloutier and C. Lineberry and A. Cato},
  journal={Anesthesia & Analgesia},
  • S. Basta, H. Ali, +5 authors A. Cato
  • Published 1982
  • Medicine
  • Anesthesia & Analgesia
  • Atracurium, a new non-depolarizing neuromuscular blocking agent, was studied in 70 patients anesthetized with fentanyl, thiopental, and nitrous oxide-oxygen. The dose found to produce 95% twitch inhibition (ED95) was 0.2 mg/ kg. The onset time from injection to maximum depression of twitch was 4.0 minutes at this dose; the duration to 95% recovery was 44.1 minutes. Twice the ED95 dose (0.4 mg/kg) had an onset time of 1.7 minutes and a duration of 63.5 minutes. No cardiovascular effects were… CONTINUE READING
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