Clinical Pharmacokinetics of Tiaprofenic Acid and its Enantiomers

@article{Davies1996ClinicalPO,
  title={Clinical Pharmacokinetics of Tiaprofenic Acid and its Enantiomers},
  author={N. M. Davies},
  journal={Clinical Pharmacokinetics},
  year={1996},
  volume={31},
  pages={331-347}
}
  • N. M. Davies
  • Published 1996
  • Chemistry, Medicine
  • Clinical Pharmacokinetics
  • SummaryTiaprofenic acid is a chiral nonsteroidal anti-inflammatory drug (NSAID) of the 2-arylpropionic acid (2-APA) class. A common structural feature of 2-APA NSAIDs is a sp3-hybridised tetrahedral chiral carbon heteroatom within the propionic acid side chain moiety, with the S-enantiomer possessing most of the beneficial anti-inflammatory activity. However, all tiaprofenic acid preparations to date are marketed as the racemate. Tiaprofenic acid has been suggested to exhibit limited… CONTINUE READING

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