Clinical Pharmacokinetics of Tiaprofenic Acid and its Enantiomers
@article{Davies1996ClinicalPO, title={Clinical Pharmacokinetics of Tiaprofenic Acid and its Enantiomers}, author={Neal M. Davies}, journal={Clinical Pharmacokinetics}, year={1996}, volume={31}, pages={331-347} }
SummaryTiaprofenic acid is a chiral nonsteroidal anti-inflammatory drug (NSAID) of the 2-arylpropionic acid (2-APA) class. A common structural feature of 2-APA NSAIDs is a sp3-hybridised tetrahedral chiral carbon heteroatom within the propionic acid side chain moiety, with the S-enantiomer possessing most of the beneficial anti-inflammatory activity. However, all tiaprofenic acid preparations to date are marketed as the racemate. Tiaprofenic acid has been suggested to exhibit limited…
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