Clinical Pharmacokinetics of Tiaprofenic Acid and its Enantiomers

@article{Davies1996ClinicalPO,
  title={Clinical Pharmacokinetics of Tiaprofenic Acid and its Enantiomers},
  author={N. M. Davies},
  journal={Clinical Pharmacokinetics},
  year={1996},
  volume={31},
  pages={331-347}
}
  • N. M. Davies
  • Published 1996
  • Chemistry, Medicine
  • Clinical Pharmacokinetics
    • SummaryTiaprofenic acid is a chiral nonsteroidal anti-inflammatory drug (NSAID) of the 2-arylpropionic acid (2-APA) class. A common structural feature of 2-APA NSAIDs is a sp3-hybridised tetrahedral chiral carbon heteroatom within the propionic acid side chain moiety, with the S-enantiomer possessing most of the beneficial anti-inflammatory activity. However, all tiaprofenic acid preparations to date are marketed as the racemate. Tiaprofenic acid has been suggested to exhibit limited… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 69 REFERENCES
    Clinical Pharmacokinetics of Ketoprofen and Its Enantiomers
    • 181
    Clinical Pharmacokinetics of Flurbiprofen and its Enantiomers
    • 101
    The correlation between blood levels of ibuprofen and clinical analgesic response
    • 208
    Clinical Pharmacokinetics of Ketorolac Tromethamine
    • 104
    Pharmacokinetics of the enantiomers of tiaprofenic acid in humans.
    • 55
    Identification of risk for renal insufficiency from nonsteroidal anti-inflammatory drugs.
    • 158
    Etodolac Clinical Pharmacokinetics
    • 49
    Negligible excretion of unchanged ketoprofen, naproxen, and probenecid in urine.
    • 110
    Phototoxic reactions to piroxicam, naproxen and tiaprofenic acid.
    • 107
    An Improved Chiral Stationary Phase for the Chromatographic Separation of Underivatized Naproxen Enantiomers
    • 127