Clinical Pharmacokinetics of Thalidomide

@article{Teo2004ClinicalPO,
  title={Clinical Pharmacokinetics of Thalidomide},
  author={S. Teo and W. Colburn and W. Tracewell and K. Kook and D. Stirling and M. Jaworsky and M. Scheffler and S. Thomas and O. Laskin},
  journal={Clinical Pharmacokinetics},
  year={2004},
  volume={43},
  pages={311-327}
}
Thalidomide is a racemic glutamic acid derivative approved in the US for erythema nodosum leprosum, a complication of leprosy. In addition, its use in various inflammatory and oncologic conditions is being investigated.Thalidomide interconverts between the (R)- and (S)-enantiomers in plasma, with protein binding of 55% and 65%, respectively. More than 90% of the absorbed drug is excreted in the urine and faeces within 48 hours. Thalidomide is minimally metabolised by the liver, but is… Expand
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Paper Mentions

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