Clinical Pharmacokinetics of Selective Serotonin Reuptake Inhibitors

  title={Clinical Pharmacokinetics of Selective Serotonin Reuptake Inhibitors},
  author={J. Harten},
  journal={Clinical Pharmacokinetics},
  • J. Harten
  • Published 1993
  • Clinical Pharmacokinetics
  • SummaryA feature common to all selective serotonin reuptake inhibitors (SSRIs) is that they are believed to act as antidepressant drugs because of their ability to reversibly block the reuptake of serotonin (5-hydroxytryptamine; 5-HT) in the synaptic cleft. From a chemical perspective, however, they show distinct differences. Consequently, the pharmacokinetic behaviour of the drugs can be very different, and these pharmacokinetic differences may have a major influence on their clinical profiles… CONTINUE READING
    The pharmacogenetics of the selective serotonin reuptake inhibitors
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    • Highly Influenced