Clinical Pharmacokinetics of Prednisone and Prednisolone

@article{Pickup1979ClinicalPO,
  title={Clinical Pharmacokinetics of Prednisone and Prednisolone},
  author={M. Pickup},
  journal={Clinical Pharmacokinetics},
  year={1979},
  volume={4},
  pages={111-128}
}
  • M. Pickup
  • Published 1979
  • Medicine
  • Clinical Pharmacokinetics
SummaryPrednisone and prednisolone are used in a wide variety of diseases. The two compounds are metabolically interconvertible; prednisolone is assumed to be the pharmacologically active species.Prednisone and prednisolone plasma concentrations are commonly determined by either radioimmunoassay or competitive protein binding techniques. No relationship has been demonstrated between prednisolone plasma concentration (unbound or total concentration) and clinical response; alternate day dosage… Expand
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