Clinical Pharmacokinetics of Paracetamol

@article{Forrest1982ClinicalPO,
  title={Clinical Pharmacokinetics of Paracetamol},
  author={John A. H. Forrest and Judith A. Clements and Laurie F. Prescott},
  journal={Clinical Pharmacokinetics},
  year={1982},
  volume={7},
  pages={93-107}
}
SummaryIn therapeutic doses paracetamol is a safe analgesic, but in overdosage it can cause severe hepatic necrosis. Following oral administration it is rapidly absorbed from the gastrointestinal tract, its systemic bioavailability being dose-dependent and ranging from 70 to 90%. Its rate of oral absorption is predominantly dependent on the rate of gastric emptying, being delayed by food, propantheline, pethidine and diamorphine and enhanced by metoclopramide. Paracetamol is also well absorbed… 

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Pharmacokinetics of Paracetamol in Göttingen Minipigs: In Vivo Studies and Modeling to Elucidate Physiological Determinants of Absorption

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