Clinical Pharmacokinetics of Oral Contraceptive Steroids
@article{Orme1983ClinicalPO, title={Clinical Pharmacokinetics of Oral Contraceptive Steroids}, author={M. Orme and D. Back and A. Breckenridge}, journal={Clinical Pharmacokinetics}, year={1983}, volume={8}, pages={95-136} }
SummaryOral contraceptive steroids are of 2 types: oestrogens, of which ethinyloestradiol is the most important, and progestagens, of which levonorgestrel and norethisterone are the most commonly used. All these steroids can be measured by a number of analytical techniques but there is little doubt that radioimmunoassay is the most convenient. All the steroids are well absorbed in humans but while levonorgestrel is completely bioavailable, norethisterone has an average bioavailability of 70… CONTINUE READING
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References
SHOWING 1-10 OF 271 REFERENCES
Comparative metabolism of 17alpha-ethynyl steroids used in oral contraceptives.
- Medicine
- Journal of toxicology and environmental health
- 1977
- 50
Metabolism of synthetic steroids by animals and man.
- Biology, Medicine
- Acta endocrinologica. Supplementum
- 1974
- 63
Comparative studies of the ethynyl estrogens used in oral contraceptives. II. Antiovulatory potency.
- Medicine
- American journal of obstetrics and gynecology
- 1975
- 38
THE METABOLIC FATE OF ORALLY ADMINISTERED 3H-NORETHYNODREL AND 3H-NORETHINDRONE IN HUMANS.
- Chemistry, Medicine
- Biochemical pharmacology
- 1963
- 38
Effect of oral contraceptives on drug metabolism
- Medicine
- Clinical pharmacology and therapeutics
- 1974
- 50
Metabolism of oral contraceptive drugs. The formation and disappearance of metabolites of norethindrone and mestranol after intravenous and oral administration.
- Medicine
- American journal of obstetrics and gynecology
- 1976
- 17
EFFECTS ON SEX HORMONE BINDING GLOBULIN OF DIFFERENT ORAL CONTRACEPTIVES CONTAINING NORETHISTERONE AND LYNESTRENOL
- Medicine
- British journal of obstetrics and gynaecology
- 1980
- 24
Metabolism of oral contraceptives. II. Metabolism of norethynodrel in women.
- Medicine
- Xenobiotica; the fate of foreign compounds in biological systems
- 1972
- 9
A study of interaction of low-dose combination oral contraceptive with Ampicillin and Metronidazole.
- Medicine
- Contraception
- 1980
- 68