Clinical Pharmacokinetics of Nimesulide

@article{Bernareggi1998ClinicalPO,
  title={Clinical Pharmacokinetics of Nimesulide},
  author={A. Bernareggi},
  journal={Clinical Pharmacokinetics},
  year={1998},
  volume={35},
  pages={247-274}
}
Nimesulide is a selective COX-2 inhibitor used in a variety of inflammatory, pain and fever states. After healthy volunteers received oral nimesulide 100mg in tablet, granule or suspension form the drug was rapidly and extensively absorbed. Mean peak concentrations (Cmax) of 2.86 to 6.50 mg/L were achieved within 1.22 to 2.75 hours of administration. The presence of food did not reduce either the rate or extent of nimesulide absorption. When nimesulide was administered in the suppository form… Expand
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