Clinical Pharmacokinetics of Imipramine and Desipramine

@article{Sallee1990ClinicalPO,
  title={Clinical Pharmacokinetics of Imipramine and Desipramine},
  author={Floyd R. Sallee and B. G. Pollock},
  journal={Clinical Pharmacokinetics},
  year={1990},
  volume={18},
  pages={346-364}
}
  • F. Sallee, B. Pollock
  • Published 1 May 1990
  • Medicine, Biology, Psychology
  • Clinical Pharmacokinetics
SummaryThe pharmacokinetics of Imipramine and desipramine have been extensively investigated with recent studies designed to understand sources of intersubject variability and to study discrete clinical populations rather than healthy volunteers. Sources of intersubject variability in pharmacokinetics are both genetic (oxidative phenotype) and environmental. Oxidative phenotype has an important impact on first-pass metabolism. In individuals with poor metabolism, systemic availability for… 
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