Clinical Pharmacokinetics of Ibuprofen
@article{Davies1998ClinicalPO, title={Clinical Pharmacokinetics of Ibuprofen}, author={N. M. Davies}, journal={Clinical Pharmacokinetics}, year={1998}, volume={34}, pages={101-154} }
Ibuprofen is a chiral nonsteroidal anti-inflammatory drug (NSAID) of the 2 arylpropionic acid (2-APA) class. A common structural feature of 2-APA NSAIDs is a sp3-hybridised tetrahedral chiral carbon atom within the propionic acid side chain moiety with the S-(+)-enantiomer possessing most of the beneficial anti-inflammatory activity. Ibuprofen demonstrates marked stereoselectivity in its pharmacokinetics. Substantial unidirectional inversion of the R-(−) to the S-(+) enantiomer occurs and thus… CONTINUE READING
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