Clinical Pharmacokinetics of Ibuprofen

@article{Davies1998ClinicalPO,
  title={Clinical Pharmacokinetics of Ibuprofen},
  author={N. M. Davies},
  journal={Clinical Pharmacokinetics},
  year={1998},
  volume={34},
  pages={101-154}
}
  • N. M. Davies
  • Published 1998
  • Chemistry, Medicine
  • Clinical Pharmacokinetics
  • Ibuprofen is a chiral nonsteroidal anti-inflammatory drug (NSAID) of the 2 arylpropionic acid (2-APA) class. A common structural feature of 2-APA NSAIDs is a sp3-hybridised tetrahedral chiral carbon atom within the propionic acid side chain moiety with the S-(+)-enantiomer possessing most of the beneficial anti-inflammatory activity. Ibuprofen demonstrates marked stereoselectivity in its pharmacokinetics. Substantial unidirectional inversion of the R-(−) to the S-(+) enantiomer occurs and thus… CONTINUE READING
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