Clinical Pharmacokinetics of Ibuprofen

  title={Clinical Pharmacokinetics of Ibuprofen},
  author={N. M. Davies},
  journal={Clinical Pharmacokinetics},
  • N. M. Davies
  • Published 1998
  • Chemistry, Medicine
  • Clinical Pharmacokinetics
  • Ibuprofen is a chiral nonsteroidal anti-inflammatory drug (NSAID) of the 2 arylpropionic acid (2-APA) class. A common structural feature of 2-APA NSAIDs is a sp3-hybridised tetrahedral chiral carbon atom within the propionic acid side chain moiety with the S-(+)-enantiomer possessing most of the beneficial anti-inflammatory activity. Ibuprofen demonstrates marked stereoselectivity in its pharmacokinetics. Substantial unidirectional inversion of the R-(−) to the S-(+) enantiomer occurs and thus… CONTINUE READING
    208 Citations

    Paper Mentions

    Interventional Clinical Trial
    The investigators will examine the effectiveness of non-opioid analgesia (Paracetamol versus Ibuprofen) in the early postpartum period  
    Interventional Clinical Trial
    This is a single centre, randomised, double-blind, double-dummy, parallel group, multiple-dose, active and placebo-controlled efficacy study to evaluate the efficacy and safety of… Expand
    InterventionDrug, Other
    Enantioselective Pharmacokinetics of Ibuprofen and Involved Mechanisms
    • 65
    Stereoselectivity of ibuprofen metabolism and pharmacokinetics following the administration of the racemate to healthy volunteers
    • 72
    • Highly Influenced
    Pharmacokinetic interaction of ibuprofen enantiomers in rabbits
    • 8
    Clinical Pharmacokinetics of Oxaprozin
    • N. M. Davies
    • Chemistry, Medicine
    • Clinical pharmacokinetics
    • 1998
    • 15
    Solubility of ( ± )-Ibuprofen and S ( + )-Ibuprofen in the Presence of Cosolvents and Cyclodextrins
    • 26
    Pharmacologic, pharmacodynamic, and pharmacokinetic considerations with intravenous Ibuprofen lysine.
    • E. Capparelli
    • Medicine
    • The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
    • 2007
    • 2
    Influence of age on the enantiomeric disposition of ibuprofen in healthy volunteers.
    • 17
    Chiral pharmacokinetics and inversion of enantiomers of a new quinoxaline topoisomerase IIbeta poison in the rat.
    • 14
    • PDF


    Clinical Pharmacokinetics of Tiaprofenic Acid and its Enantiomers
    • N. M. Davies
    • Chemistry, Medicine
    • Clinical pharmacokinetics
    • 1996
    • 20
    Clinical Pharmacokinetics of Flurbiprofen and its Enantiomers
    • N. M. Davies
    • Chemistry, Medicine
    • Clinical pharmacokinetics
    • 1995
    • 101
    Etodolac Clinical Pharmacokinetics
    • 48
    Clinical Pharmacokinetics of Ketoprofen and Its Enantiomers
    • 183
    Clinical Pharmacokinetics of Naproxen
    • 91
    Clinical Pharmacokinetics of Ketorolac Tromethamine
    • 107