Clinical Pharmacokinetics of Ibuprofen

@article{Davies1998ClinicalPO,
  title={Clinical Pharmacokinetics of Ibuprofen},
  author={Neal M. Davies},
  journal={Clinical Pharmacokinetics},
  year={1998},
  volume={34},
  pages={101-154}
}
  • N. Davies
  • Published 1 February 1998
  • Medicine, Biology, Chemistry
  • Clinical Pharmacokinetics
Ibuprofen is a chiral nonsteroidal anti-inflammatory drug (NSAID) of the 2 arylpropionic acid (2-APA) class. A common structural feature of 2-APA NSAIDs is a sp3-hybridised tetrahedral chiral carbon atom within the propionic acid side chain moiety with the S-(+)-enantiomer possessing most of the beneficial anti-inflammatory activity. Ibuprofen demonstrates marked stereoselectivity in its pharmacokinetics. Substantial unidirectional inversion of the R-(−) to the S-(+) enantiomer occurs and thus… 
Stereoselectivity of ibuprofen metabolism and pharmacokinetics following the administration of the racemate to healthy volunteers
TLDR
The stereoselective metabolism and pharmacokinetics of the enantiomers of ibuprofen have been investigated following the oral administration of the racemic drug to 12 healthy volunteers and analysis of the stereochemical composition of the urinary excretion products indicated that 68% of the dose of (R) -ib uprofen had undergone chiral inversion.
Pharmacokinetic interaction of ibuprofen enantiomers in rabbits
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The enantiomeric interaction in the pharmacokinetic behaviour of ibuprofen after racemic administration is considered to be a result of an alteration in the metabolic or excretion phase (or both) rather than stereoselective protein binding in the systemic distribution.
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  • 1998
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The lack of interaction between bazedoxifene and ibuprofen suggests that they may be coadministered without dose adjustment, and the increase in bazedxifene plasma concentrations when combined with ib uprofen versus bazed oxifene alone is unlikely to be clinically significant.
Stereoconfiguration of antiallergic and immunologic drugs.
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  • Medicine, Biology
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • 2008
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TLDR
The pharmacokinetic parameters of rectal administration of ibuprofen between enema and suppository form were compared in order to provide evidence for the faster absorption rates of ib uprofen enema to provide faster onset of analgesic and antipyretic benefit.
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