Clinical Pharmacokinetics of Ethanol

@article{Holford1987ClinicalPO,
  title={Clinical Pharmacokinetics of Ethanol},
  author={N. Holford},
  journal={Clinical Pharmacokinetics},
  year={1987},
  volume={13},
  pages={273-292}
}
  • N. Holford
  • Published 1987
  • Chemistry, Medicine
  • Clinical Pharmacokinetics
SummaryThe pharmacokinetics of ethanol after typical doses are described by a 1-compartment model with concentration-dependent elimination. The volume of distribution estimated from blood concentrations is about 37 L/70kg. Protein binding of ethanol has not been reported. Elimination is principally by metabolism in the liver with small amounts excreted in the breath (0.7%), urine (0.3%), and sweat (0.1%). Metabolism occurs, principally by alcohol dehydrogenase, in the liver to acetaldehyde… Expand

Paper Mentions

Interventional Clinical Trial
The aim of the study is to study the profile of ethanol and non-oxidative biomarkers (ethyl glucuronide, ethyl sulphate and fatty acid ethyl esters) after experimental administration of… Expand
ConditionsAlcohol Consumption, Healthy
InterventionDietary Supplement
Role of Variability in Explaining Ethanol Pharmacokinetics
Noncompetitive-like inhibition of ethanol elimination by cyanamide treatment: pharmacokinetic study.
Pharmacokinetics of Ethanol - Issues of Forensic Importance.
  • A. Jones
  • Medicine, Chemistry
  • Forensic science review
  • 2011
Application of a physiologically based pharmacokinetic model to estimate the bioavailability of ethanol in male rats: distinction between gastric and hepatic pathways of metabolic clearance.
  • G. Pastino, R. Conolly
  • Chemistry, Medicine
  • Toxicological sciences : an official journal of the Society of Toxicology
  • 2000
The Pharmacokinetics of Methanol in the Presence of Ethanol
A human PBPK model for ethanol describing inhibition of gastric motility
Effect of acute ethanol administration on toloxatone pharmacokinetics in rabbits.
Ethanol kinetics: extent of error in back extrapolation procedures.
Elimination and phase II metabolism of ethanol in camels after intravenous administration.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 58 REFERENCES
Effects of Ethanol on Drug and Metabolite Pharmacokinetics
The metabolism and pharmacokinetics of alcohol in man.
  • P. Mullen
  • Chemistry, Medicine
  • Journal - Forensic Science Society
  • 1977
Ethanol 'dose-dependent' elimination: Michaelis-Menten v classical kinetic analysis.
Aging and ethanol metabolism
Effect of intravenous infusions of ethanol upon estimated hepatic blood flow in man.
  • A. Mendeloff
  • Medicine
  • The Journal of clinical investigation
  • 1954
Absorption, distribution and elimination of alcohol: highway safety aspects.
  • K. Dubowski
  • Medicine
  • Journal of studies on alcohol. Supplement
  • 1985
...
1
2
3
4
5
...