Clinical Pharmacokinetics of Clonidine

@article{Lowenthal1988ClinicalPO,
  title={Clinical Pharmacokinetics of Clonidine},
  author={D. Lowenthal and K. Matzek and T. Macgregor},
  journal={Clinical Pharmacokinetics},
  year={1988},
  volume={14},
  pages={287-310}
}
SummaryClonidine is a centrally active antihypertensive agent effective in the treatment of mild, moderate and severe hypertension, alone or in combination with other drugs. Use of oral clonidine has often been limited by side effects which include dry mouth and drowsiness. Transdermal clonidine was therefore developed as an alternative to oral therapy.Ideally, a drug administered at a constant rate into the systemic circulation should attain steady-state concentrations with less peak-to-trough… Expand
143 Citations
The pharmacokinetics of clonidine in high dosage
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Pharmacokinetic Characterisation of Transdermal Delivery Systems
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