Clinical Pharmacokinetics of Cannabinoids

  title={Clinical Pharmacokinetics of Cannabinoids},
  author={Franjo Grotenhermen},
Absorption and metabolism of tetrahydrocannabinol (THC) vary as a function of route of administration. Pulmonary assimilation of inhaled THC causes a maximum plasma concentration within minutes, while psychotropic effects start within seconds to a few minutes, reach a maximum after 15 to 30 minutes, and taper off within 2 to 3 hours. Following oral ingestion, psychotropic effects set in with a delay of 30 to 90 minutes, reach their maximum after 2 to 3 hours, and last for about 4 to 12 hours… CONTINUE READING


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