Clinical Pharmacokinetics of Amantadine Hydrochloride

@article{Aoki1988ClinicalPO,
  title={Clinical Pharmacokinetics of Amantadine Hydrochloride},
  author={F. Aoki and D. Sitar},
  journal={Clinical Pharmacokinetics},
  year={1988},
  volume={14},
  pages={35-51}
}
  • F. Aoki, D. Sitar
  • Published 1988
  • Chemistry, Medicine
  • Clinical Pharmacokinetics
SummaryAmantadine is a drug with diverse uses ranging from prevention of influenza A illness to the treatment of patients with Parkinson’s disease. It is available only in oral formulations from which it is well absorbed and widely distributed, little drug being present in the circulation. Apparent volume of distribution is inversely related to dose over the therapeutic range and accounts in part for a noteworthy logarithmic increase in plasma concentration as a function of dose. Elimination is… Expand
166 Citations

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