Clinical Pharmacokinetics of Alprazolam

  title={Clinical Pharmacokinetics of Alprazolam},
  author={D. Greenblatt and C. Wright},
  journal={Clinical Pharmacokinetics},
  • D. Greenblatt, C. Wright
  • Published 1993
  • Medicine
  • Clinical Pharmacokinetics
  • SummaryAlprazolam is a triazolobenzodiazepine that is extensively prescribed in the Western world for the treatment of anxiety and panic disorders. Its benzodiazepine receptor binding characteristics are qualitatively similar to those of other benzodiazepines. The drug is metabolised primarily by hepatic microsomal oxidation, yielding α-hydroxy- and 4-hydroxy-alprazolam as principal initial metabolites. Both have lower intrinsic benzodiazepine receptor affinity than alprazolam and appear in… CONTINUE READING
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