Clinical Pharmacokinetics of 5-Fluorouracil and Its Metabolites in Plasma , Urine , and Bile 1

Abstract

Kinetics of 5-fiuorouracil (FUra) and FUra metabolites in plasma and urine were investigated in 10 cancer patients following i.v. bolus admin istration of 500 mg/m2 FUra with 600 nCi of |6-3H|FUra. Biliary excre tion was examined in two patients with external biliary catheters. Quantitation of unchanged drug and metabolites was assessed by a highly specific… (More)

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