Clinical Pharmacokinetics and Pharmacodynamics of Tacrolimus in Solid Organ Transplantation

  title={Clinical Pharmacokinetics and Pharmacodynamics of Tacrolimus in Solid Organ Transplantation},
  author={C. Staatz and S. Tett},
  journal={Clinical Pharmacokinetics},
  • C. Staatz, S. Tett
  • Published 2004
  • Medicine
  • Clinical Pharmacokinetics
  • The aim of this review is to analyse critically the recent literature on the clinical pharmacokinetics and pharmacodynamics of tacrolimus in solid organ transplant recipients.Dosage and target concentration recommendations for tacrolimus vary from centre to centre, and large pharmacokinetic variability makes it difficult to predict what concentration will be achieved with a particular dose or dosage change. Therapeutic ranges have not been based on statistical approaches. The majority of… CONTINUE READING
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