Clinical Pharmacokinetics Pethidine

@article{Mather1978ClinicalPP,
  title={Clinical Pharmacokinetics Pethidine},
  author={Laurence E. Mather and Peter J. Meffin},
  journal={Clinical Pharmacokinetics},
  year={1978},
  volume={3},
  pages={352-368}
}
Pethidine is commonly used in single doses as a preoperative medication or in multiple doses as an analgesic. The clinical consequences of altered disposition are more likely to result from its analgesic use. Correlations between plasma pethidine concentration, analgesia and side effects such as respiratory depression, have been established, but considerable overlap exists between concentrations producing therapeutic and non-therapeutic effects. The current practice of intermittent pethidine… 
Clinical Pharmacokinetics of Pethidine: 1982
TLDR
The use of continuous intravenous infusions of pethidine appears to be a rational new approach to acute pain management, and further studies assessing the effect of metabolites, protein binding, age, personality and source of pain on the pETHidine concentrationanalgesic response relationship are needed.
The minimum effective analgetic blood concentration of pethidine in patients with intractable pain.
TLDR
Pethidine infusions were performed in 16 patients with intractable pain in order to define a minimum effective analgetic blood concentration range and the pharmacokinetic properties of pethidine found in the majority of these patients were in the range considered to be normal.
Patient-controlled Analgesic Therapy, Part II: Individual Analgesic Demand and Analgesic Plasma Concentrations of Pethidine in Postoperative Pain
TLDR
Individual consumption of pethidine was consistent, with stable plasma concentrations throughout most of the trial period, and Pseudo-steady-state plasma concentrations of peltidine were established and maintained at widely different levels.
Meperidine: therapeutic use and toxicity.
Regional Epidural Analgesia: Kinetics of Pethidine
TLDR
Preliminary pharmacokinetic data from six patients show that epidural doses of 20 or 60 mg pethidine give a similar pattern of absorption and elimination in plasma as 1 mgpethidine/kg body weight intramuscularly, and the possibility cannot be excluded that the analgesic effect of epidural peltidine is partly systemically mediated.
Patient-controlled Analgesic Therapy, Part I: Pharmacokinetics of Pethidine in the Per- and Postoperative Periods
TLDR
The influence of anaesthesia and surgery on the pharmacokinetic parameters of pethidine (meperidine) was studied in 12 patients and changes in elimination half-life and plasma clearance are significant.
Pharmacokinetics of Opioids in Renal Dysfunction
TLDR
Case reports of prolonged narcosis associated with the use of both codeine and dihydrocodeine in patients with renal insufficiency call for care to be used when prescribing these agents under such conditions.
Pethidine clearance during continuous intravenous infusions in postoperative patients.
TLDR
Pethidine clearance and steady state concentration were predictable retrospectively from linear multivariable equations involving simple physical characteristics of the patient.
Clinical Pharmacokinetics of Fentanyl and its Newer Derivatives
  • L. Mather
  • Medicine, Biology
    Clinical pharmacokinetics
  • 1983
TLDR
Fentanyl is rightly regarded as having a redistribution-limited duration of action after single or infrequent doses (analogous to thiopentone), but the magnitude of the pharmacokinetic constants reported for fentanyl are remarkably inconsistent even in healthy volunteers.
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References

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TLDR
Patients appeared to be less sensitive to these effects at similar plasma drug concentrations, possibly because of catecholamine-mediated stimulus, suggesting that plasma concentrations may be a poor guide to the clinical response in patient-volunteer comparison.
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TLDR
A comparison of the peak serum concentration, the biologic half-life, and the serum concentration-time curve resulting from the administration of two different preparations of meperidine should prove the bioequivalencc or inequivalence of the preparations.
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TLDR
The plasma concentration‐time profiles of meperidine following intravenous injection in surgical patients and volunteers were investigated by reference to a classical two‐compartment open model and factors may relate directly to clinical observations that heavy alcohol consumers tend to be more refractory to central nervous system (CNS) depressants and that elderly patients are more susceptible to respiratory depression from narcotics.
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TLDR
Monitoring of serum levels after the administration of 1.5 mg/kg intramuscularly to a group of young and old subjects found red cell binding of pethidine by the young was much greater than by the old, which would explain the high serum levels in the old and the increased incidence of side effects.
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TLDR
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TLDR
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TLDR
The increased toxicity of potent analgesics in combination with MAO inhibitors is not due to a decelerated metabolism of the analgesic drug, but is related to an increased concentration of cerebral 5‐hydroxytryptamine.
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Pethidine given intravenously to a pregnant patient began to reach the foetus in measurable quantities within 2 minutes. The level of concentration in cord blood fell exponentially, parallel to, but
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