Clinical Pharmacokinetics Pethidine

@article{Mather1978ClinicalPP,
  title={Clinical Pharmacokinetics Pethidine},
  author={L. Mather and P. Meffin},
  journal={Clinical Pharmacokinetics},
  year={1978},
  volume={3},
  pages={352-368}
}
  • L. Mather, P. Meffin
  • Published 1978
  • Medicine
  • Clinical Pharmacokinetics
  • Pethidine is commonly used in single doses as a preoperative medication or in multiple doses as an analgesic. The clinical consequences of altered disposition are more likely to result from its analgesic use. Correlations between plasma pethidine concentration, analgesia and side effects such as respiratory depression, have been established, but considerable overlap exists between concentrations producing therapeutic and non-therapeutic effects. The current practice of intermittent pethidine… CONTINUE READING

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