Clinical Pharmacogenetics Implementation Consortium guidelines for HLA-B genotype and carbamazepine dosing.

@article{Leckband2012ClinicalPI,
  title={Clinical Pharmacogenetics Implementation Consortium guidelines for HLA-B genotype and carbamazepine dosing.},
  author={Susan G Leckband and John R Kelsoe and Henry M. Dunnenberger and Alfred L. George and Ellie Tran and Raoul Berger and Daniel J M{\"u}ller and Michelle Whirl-Carrillo and Kelly E. Caudle and Munir Pirmohamed},
  journal={Clinical pharmacology and therapeutics},
  year={2012},
  volume={94 3},
  pages={
          324-8
        }
}
Human leukocyte antigen B (HLA-B) is a gene that encodes a cell surface protein involved in presenting antigens to the immune system. The variant allele HLA-B*15:02 is associated with an increased risk of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in response to carbamazepine treatment. We summarize evidence from the published literature supporting this association and provide recommendations for the use of carbamazepine based on HLA-B genotype (also available on… CONTINUE READING
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