Clinical Originality and New Biology of Trimipramine

  title={Clinical Originality and New Biology of Trimipramine},
  author={Markus Gastpar},
SummaryTrimipramine differs from other antidepressant drugs in a number of ways. Although trimipramine shares equivalent efficacy with doxepin, imipramine, maprotiline and amitriptyline, as evidenced by double-blind studies, it possesses a different side-effect profile. Trimipramine is considered to be less cardiotoxic, and data presented in this paper support its minimal effect on orthostatic hypotension, as compared with clomipramine. In addition, trimipramine has less epileptogenic potential… 
Side effects of adjunct light therapy in patients with major depression
The most prominent unfavourable side effects of adjunct bright-light therapy as compared with trimipramine monotherapy were aggravated sedation, persisting restlessness, emerging sleep disturbance and decreased appetite as well as the worsening of vertigo.
Patterns of toxicity and factors influencing severity in acute adult trimipramine poisoning.
It is demonstrated that moderate trimipramine poisoning can already occur after ingestion of doses in the high therapeutic range, and poisoned patients have to be monitored for central nervous system depression, dysrhythmias and QT(c) prolongation.
C. elegans, un outil de criblage pour la recherche de traitements contre les maladies rares
Les techniques de criblage actuelles (in vitro et in silico) sont dependantes des efforts menes en biologie medicinale pour identifier des cibles biologiques pertinentes ; cibles difficiles a definir
Substrates of Human CYP2D6


Trimipramine, a tricyclic antidepressant exerting atypical actions on the central noradrenergic system.
The results demonstrate that the down-regulation of central noradrenergic sensitivity in the rat is not a prerequisite for clinical efficacy of antidepressants in man.
Controlled trial of trimipramine, monoamine oxidase inhibitors, and combined treatment in depressed outpatients.
It is concluded that neither MAOIs norMAOIs combined with tricyclic antidepressants are the treatment of first choice in unselected outpatients with mild or moderate depression.
Systematic studies with trimipramine--a new antidepressive drug.
T trimipramine was initially screened and evaluated in France where the pre-clinical and the clinical aspects of the drug were exten­ sively studied by Julou, Dutertre, and by Lambert and his associates.
A Comparative Double‐Blind Controlled Study of Trimipramine and Amitriptyline in Major Depression: Lack of Correlation with 5‐Hydroxytryptamine Reuptake Blockade
This finding constitutes the first clinical evidence that trimipramine does not exert its anti-depressant effect through 5-hydroxytryptamine reuptake blockade, and it is proposed that neuronal sensitization to 5-HydroxyTryptamine might mediate the therapeutic effect of tricyclic antidepres-sant drugs.
Seizures with Antidepressants: An In Vitro Technique to Assess Relative Risk
The assumption that neuroleptics have greater epileptogenic potential than antidepressants is questioned as the relative potential of various antidepressants to induce seizures while being used at therapeutic doses was studied.
A comparative trial of the antidepressant, anxiolytic, and cardiovascular effects of trimipramine and doxepin in depressed hospitalized patients.
Comparisons over time revealed that both drugs improved patients' overall well-being as indicated by the rating scales studied, and the total number of side effects reported was greater in the doxepin-treated patients.
Trimipramine and maprotiline: antidepressant, anxiolytic, and cardiotoxic comparison.
Both groups showed significant improvement over time, with no difference between the groups on the Severity and Improvement factors of the Clinical Global Impression scale, on the total and factor subscales of the Hamilton Depression Rating Scale, and on the Anxiety Status Inventory.
Uptake inhibition of biogenic amines by newer antidepressant drugs: Relevance to the dopamine hypothesis of depression
The dopamine theory of depression was studied by assessing the effect of antidepressant drugs on uptake of dopamine, noradrenaline, and serotonin in synaptosomes from rat brain, and five newer drugs showed rather potent inhibition of 3H-dopamine uptake in corpus striatum.
Comparison of tricyclic antidepressants in rabbits: Antinociception and potentiation of the noradrenaline pressor responses
It is concluded that antinociception by tricyclic antidepressants is more likely related to their central tryptaminergic mechanisms or to local anaesthetic properties than to their adrenergic or adrenolytic activity.
Pharmacokinetic and clinical parameters of zopiclone and trimipramine when administered simultaneously to volunteers.
It is concluded that zopiclone presents advantages over some other sedative drugs as it is rapidly absorbed and eliminated and the decrease in the relative bioavailability of trimipramine may be clinically significant.