Clinical Manifestations and Molecular Characterization of Pertactin-Deficient and Pertactin-Producing Bordetella pertussis in Children, Philadelphia 2007-2014.

@article{Vodzak2017ClinicalMA,
  title={Clinical Manifestations and Molecular Characterization of Pertactin-Deficient and Pertactin-Producing Bordetella pertussis in Children, Philadelphia 2007-2014.},
  author={Jennifer Vodzak and Anne Marie Queenan and Emily Le Souder and Alan T Evangelista and S. Seth Long},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2017},
  volume={64 1},
  pages={
          60-66
        }
}
BACKGROUND  Bordetella pertussis strains lacking expression of pertactin, a bacterial adhesin and vaccine target, are emerging. There are limited data on disease manifestations of mutant strains in children. We sought to compare clinical manifestations of pertactin-deficient and pertactin-producing B. pertussis infection in infants and describe corresponding molecular characteristics. METHODS  Molecular characterization of archived B. pertussis isolates (collected January 2007 to March 2014… CONTINUE READING