Corpus ID: 3553314

Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome : Part II — Use of Immunomodulatory Therapies

@inproceedings{Frankovich2017ClinicalMO,
  title={Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome : Part II — Use of Immunomodulatory Therapies},
  author={Jennifer Frankovich and Susan E. Swedo and Tanya K. Murphy and Russell C. Dale and Dritan Agalliu and Kyle Allen Williams and M C Daines and Mady Hornig and Harry T. Chugani and Terry D. Sanger and Eyal Muscal and Mark S. Pasternack and Michael S. Cooperstock and Hayley A. Gans and Yujuan Zhang and Madeleine W. Cunningham and Gail A. Bernstein and Reuven Bromberg and Theresa Willett and Kayla D Brown and Bahare Farhadian and Kiki D. Chang and Daniel A. Geller and Joseph D Hernandez and Janell Sherr and Richard Shaw and Elizabeth Latimer and James Frederick Leckman and Margo Thienemann},
  year={2017}
}
Introduction: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is a clinically heterogeneous disorder with a number of different etiologies and disease mechanisms. Inflammatory and postinfectious autoimmune presentations of PANS occur frequently, with some clinical series documenting immune abnormalities in 75%–80% of patients. Thus, comprehensive treatment protocols must include immunological interventions, but their use should be reserved only for PANS cases in which the symptoms… Expand

Tables from this paper

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TLDR
A positive effect of acute and prophylactic antibiotic-, psychiatric- and immunomodulating treatment, according to parental reports is shown. Expand
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Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome : Part III — Treatment and Prevention of Infections
Objectives: Pediatric acute-onset neuropsychiatric syndrome (PANS) and its subset, pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS), are emergingExpand
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Coricosteroids may be a helpful treatment intervention in patients with new-onset and relapsing/remitting PANS and PANDAS, hastening symptom improvement or resolution when corticosteroids are given earlier in a disease flare, symptoms improve more quickly and patients achieve clinical remission sooner. Expand
Course of Neuropsychiatric Symptoms After Introduction and Removal of Nonsteroidal Anti-Inflammatory Drugs: A Pediatric Observational Study.
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