Clinical Importance and Therapeutic Implications of the Pivotal CXCL12-CXCR4 (Chemokine Ligand-Receptor) Interaction in Cancer Cell Migration

@article{Arya2007ClinicalIA,
  title={Clinical Importance and Therapeutic Implications of the Pivotal CXCL12-CXCR4 (Chemokine Ligand-Receptor) Interaction in Cancer Cell Migration},
  author={Manit Arya and Hashim Uddin Ahmed and Nitika Silhi and Magali Williamson and Hitendra R. H. Patel},
  journal={Tumor Biology},
  year={2007},
  volume={28},
  pages={123 - 131}
}
Chemokines are small, secreted proteins and are now the largest known cytokine family. They mediate their effects through a family of G-protein-coupled receptors and were initially recognized for their ability to act as chemo-attractants and activators of specific types of leucocytes in a variety of immune and inflammatory responses. However, during the past 5 years there has been a chemokine revolution in cancer and all scientists and clinicians in oncology-related fields are now aware of… 

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