Clinical Implication and Mitotic Effect of CD44 Cleavage in Relation to Osteopontin/CD44 Interaction and Dysregulated Cell Cycle Protein in Gastrointestinal Stromal Tumor

@article{Hsu2010ClinicalIA,
  title={Clinical Implication and Mitotic Effect of CD44 Cleavage in Relation to Osteopontin/CD44 Interaction and Dysregulated Cell Cycle Protein in Gastrointestinal Stromal Tumor},
  author={MSc Kai-Hsi Hsu and Hung-Wen Tsai and P. A. Lin and Yun-Shang Hsu BSc and PhD Yan-Shen Shan and Pei-Jung Frank Lu},
  journal={Annals of Surgical Oncology},
  year={2010},
  volume={17},
  pages={2199-2212}
}
CD44 and osteopontin (OPN) are functionally related molecules that, alone or in combination, play miscellaneous biological and pathophysiologic roles. CD44 cleavage, one unique feature of CD44, occurs in human cancers, but its function remains unclear. This study aimed to assess the clinicopathologic significance and mechanism of CD44 cleavage in gastrointestinal stromal tumor (GIST) with respect to OPN and OPN/CD44 interaction. CD44 cleavage was evaluated by immunoblotting in 31 primary GIST… CONTINUE READING