Clinical Efficacy of Noninvasive Cryolipolysis and Its Effects on Peripheral Nerves

@article{Coleman2008ClinicalEO,
  title={Clinical Efficacy of Noninvasive Cryolipolysis and Its Effects on Peripheral Nerves},
  author={Sydney R. Coleman and Kulveen Sachdeva and Barbara M. Egbert and Jessica A. Preciado and John Allison},
  journal={Aesthetic Plastic Surgery},
  year={2008},
  volume={33},
  pages={482-488}
}
BackgroundCryolipolysis provides a method for noninvasive fat reduction that significantly reduces subcutaneous fat in a pig model without apparent damage to skin and surrounding structures. This study aimed to determine whether fat reduction in humans caused by cold exposure is associated with alteration in local sensory function or nerve fibers.MethodsIn this study, 10 subjects were treated with a prototype cooling device. Fat reduction was assessed in 9 of the 10 subjects via ultrasound… Expand

Paper Mentions

Interventional Clinical Trial
The purpose of this study is to evaluate the efficacy of cryotherapy on the slimming of subcutaneous fat mass in the abdomen and saddlebags. Cryotherapy is a completely non-invasive… Expand
ConditionsCryotherapy Effect, Obesity, Weight Loss
InterventionDevice
Interventional Clinical Trial
The aim of this study is to evaluate the clinical efficacy of reduction of local fat on ipsilateral thigh through cryolipolysis (zeltiq) and controlateral thigh using by amplitude… Expand
ConditionsLipolysis
InterventionDevice
Clinical effectiveness of non-invasive selective cryolipolysis
  • Jiehoon Kim, D. Kim, H. Ryu
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  • Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology
  • 2014
TLDR
Non-invasive selective cryolipolysis has been reported to be a safe and effective treatment modality for the reduction of excess adipose tissue and is a promising technology that could be an appropriate and safe therapeutic option for subcutaneous fat reduction. Expand
Noninvasive selective cryolipolysis and reperfusion recovery for localized natural fat reduction and contouring.
TLDR
Noninvasive cryolipolysis results in a predictable and noticeable fat reduction within 6 months and does not cause skin damage. Expand
Cryolipolysis for noninvasive body contouring: clinical efficacy and patient satisfaction
TLDR
In clinical studies, cryolipolysis was shown to reduce subcutaneous fat at the treatment site by up to 25% after one treatment, and the patient satisfaction rate is higher than with other technologies used for noninvasive lipolysis. Expand
Effects of Cryolipolysis on Abdominal Adiposity
TLDR
In ultrasound images, as well as in macroscopic and histological analyses, significant adipocytes destruction was detected, with consequent fat layer reduction and integrity of areas that were adjacent to the treated tissue. Expand
Non-invasive cryolipolysis to reduce subcutaneous fat in the arms
TLDR
This pilot study evaluated cryolipolysis to reduce upper arm fat using a flat vacuum applicator and found one treatment was safe and effective to reduce arm fat. Expand
Cryolipolysis for reduction of excess adipose tissue.
TLDR
Cryolipolysis is a new, noninvasive treatment option that may be of benefit in the treatment of excess adipose tissue and there have been no reports of scarring, ulceration, or alterations in blood lipid or liver function profiles. Expand
Transient alterations of cutaneous sensory nerve function by non-invasive cryolipolysis
TLDR
The data suggest that controlled skin cooling to specifically target cutaneous nerve fibers has the potential to be useful for prolonged relief of cutaneous pain and might have a use as a research tool to isolate and study cutaneous itch-sensing nerves in human skin. Expand
The Efficacy and Safety of Cryolipolysis for Subcutaneous Fat Reduction
TLDR
Noninvasive selective cryolipolysis is an effective and safe treatment modality for reducing excess fat cells in patients undergoing body contouring. Expand
ryolipolysis for Reduction of Excess Adipose Tissue
Controlled cold exposure has long been reported to be a cause of panniculitis in cases such as popsicle panniculitis. Cryolipolysis is a new technology that uses cold exposure, or energy extraction,Expand
Utilisation of Cryolipolysis among Asians: A Review on Efficacy and Safety
TLDR
Cryolipolysis utilisation among Asians or darker skin types provides the same efficacy and safety profiles as in Caucasians, and might be proposed as the first treatment choice for Asian patients who opted to do body contouring. Expand
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Cryolipolysis is worthy of further study because it has been shown to significantly decrease subcutaneous fat and change body contour without causing damage to the overlying skin and surrounding structures or deleterious changes in blood lipids. Expand
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The results indicate that all nerve populations were damaged, possibly in a cycle of ischaemia and reperfusion, in a 40-year-old man with severe non-freezing cold injury in both feet. Expand
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The results further validate the use of the rat tail as a model for non-freezing cold injury (NFCI) and suggest that the injury's etiology is multifaceted, which may require a variety of strategies and interventions to prevent its occurrence. Expand
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The pathological basis of non-freezing cold nerve injury is one of ischaemia, accelerated and enhanced by direct cold injury, suggesting a multifactorial aetiology. Expand
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TLDR
The findings supported the hypothesis that an interface is created at the site of initial nerve damage in the upper tibial region of immersed limbs, where cyclical ischaemia-reperfusion injury occurs. Expand
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TLDR
Methods to quantify epidermal nerve fibers (ENFs) in skin biopsy specimens from diabetic candidates for pancreas transplantation and control subjects constitute a basis for continued study of the effects of the euglycemia that attends successful Pancreas transplanted patients with various types of polyneuropathy. Expand
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A case of a newborn infant who developed erythematous, indurated plaques on both cheeks and right shoulder following ice pack application for supraventricular tachycardia is presented. Expand
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TLDR
Data indicate that severe ischaemia of the peripheral nerve results in reperfusion injury, functional impairment, and disruption of the BNB, indicating that oxidative stress damages the B NB and causes IFD. Expand
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